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Dr. Bethune 11th October 2005 |
Fish-dioxin and dioxin like PCBs: Icelandic people eat alot of fish, compared to the other countries listed. Fish contain more PCB content then other protein sources. Recent attention has focused on the human polymorphism of the enzymes responsible for the disposition of dioxin and dioxin-like compounds. Zhang et al. indicate that women with a variant of the cytochrome P450 1A1 (CYP 1A1) gene called m2 are at a greater risk for breast cancer when exposed to PCBs [12]. Their results are consistent with previous studies that have suggested that variations in this PCB inducible gene may affect susceptibility to PCB exposure [13-16]. 12 Zhang Y, Wise JP, Holford TR, Xie H, Boyle P, Zahm ZH, et al. Serum polychlorinated biphenyls, cytochrome P-450 1A1 Polymorphisms and risk of breast cancer in Connecticut women. Am J Epidemiol 2004;160:1177-83. 13 Li Y, Millikan RC, Bell DA , Cui L, Chiu-Kit JT, Newman B, Conway K. Polychlorinated biphenyls, cytochrome P450 1A1 (CYP1A1) polymorphisms, and breast cancer risk among African American women and white women in North Carolina: a population-based case-control study. Breast Cancer Res 2005;7:R12-R18. 14 McKinney JD, Waller CL. Polychlorinated biphenyls as hormonally active structural analogues. Environ Health Perspect 1994;102:290-7. 15 Kimbrough RD. Laboratory and human studies on polychlorinated biphenyls (PCBs) and related compounds. Environ Health Perspect 1985;59:99-106. 16 Safe S. Polychlorinated biphenyls (PCB): environmental impact, biochemical and toxic responses and implications for risk assessment. Crit Rev Toxicol 1994;24:87-149. |
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emily 1st November 2005 |
Does it matter where you came from increase or decrease the risk of breast cancer?? |
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Nick Jackalson 6th January 2006 |
Dr. Bethune, I beg to differ, because you can read in many places on the Internet that the Japanese have the highest, or at least one of the highest, fish consumptions in the world, and yet they have a very low incidence of breast cancer. The Japanese eat very little dairy products, and I expect the Icelandic eat high amounts of dairy products and also high fat in general because of the cold climate. Apart from that, the Japanese eat very high amounts of soy protein and fresh fruit and vegetables. And I also suspect, and have read in various places, that there is a genetic propensity towards breast cancer in genetically homogeneous, Nordic peoples like the Icelandic. |
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