Induction of genomic instability by HPV oncogenes E6 and E7 Polyploidy occurs as an early event during cervical carcinogenesis and predisposes cells to aneuploidy and chromosomal instability.
Expression of the HPV E6 and E7 oncogenes in human keratinocytes leads to polyploidy in response to mitotic stress and DNA damage.
Previously, it was thought that E6 and E7 induce polyploidy after microtubule disruption by abrogating the spindle checkpoint through degradation of the tumor suppressor p53 and pRb, respectively.
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