His art was well known outside ‘s-Hertogenbosch during his lifetime.
References to astrology, folklore, witchcraft, and alchemy, in addition to the theme of the Antichrist and episodes from the lives of exemplary saints, are all woven together by Bosch into a labyrinth of late medieval Christian iconography.
Scholars differ in their interpretation of Bosch's art, but most agree that his pictures show a preoccupation with the human propensity for sin in defiance of God, as well as with God's eternal damnation of lost souls in hell as a fateful consequence of human folly.