Science will continue to surprise us with what it discovers and creates; then it will astound us by devising new methods to surprises us.
For example, science papers cite other science papers, and that process of research pointing at itself invokes a whole higher level, the emergent shape of citation space.
But as science plunges into the outer limits of scale – at the largest and smallest ends – and confronts the weirdness of the fundamental principles of matter/energy/information such as that inherent in quantum effects, it may not be able to ignore the role of observer.