3TC
2'-3'-dideoxy-3'-thiacytidine
The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). The molecular mass can be calculated... Molecular Weight	229.26
Empiric Formula	C8H11N3O3S
The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. It is controlled by the WHO Collaborating Centre for Drug Statistics Methodology, and was first published in 1976. Drugs are divided into different groups according to the organ or system on which they act and/or their... ATC code	J05AF05
Metabolism	Renal elimination (ca.70%)
The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother. It does not include any risks conferred by pharmaceutical agents or their metabolites that are present in breast milk. United States... Pregnancy category	C ( The United States of America — also referred to as the United States, the U.S.A., the U.S., America¹, the States, or (archaically) Columbia — is a federal republic of 50 states located primarily in central North America (with the exception of two states: Alaska and Hawaii... USA) B3 ( Australia, officially the Commonwealth of Australia, is the sixth-largest country in the world, the only one to occupy an entire continent, and the largest in the region of Australasia/ Oceania. It also includes a number of secondary islands, the largest of which is Tasmania, an Australian State. Australia is... Aus)

Lamivudine(2'-3'-dideoxy-3'-thia Cytidine is a molecule (known as a nucleoside) that is formed when cytosine is attached to a ribose ring (also known as a ribofuranose) via a β-N1-glycosidic bond. If cytosine is attached to a deoxyribose ring, it is known as a deoxycytidine. Categories: Nucleosides ... cytidine, 3TC) is a potent Reverse transcriptase is an enzyme used by all retroviruses and retrotransposons that transcribes the genetic information from the virus or retrotransposon from RNA into DNA, which can integrate into the host genome. Eukaryotes with linear DNA uses a variant of reverse transcriptase, called telomerase, with the RNA template contained in... reverse transcriptase inhibitor. It can inhibit both types (1 and 2) of The human immunodeficiency virus (HIV) is a frequently mutating retrovirus that attacks the human immune system and which has been shown to cause acquired immune deficiency syndrome (AIDS). History The first AIDS cases were described in 1981. HIV was discovered and identified as the agent for AIDS by Luc Montagnier... HIV reverse transcriptase and also the reverse transcriptase of Originally known as serum hepatitis, Hepatitis B has only been recognized as such since World War II, and has caused current epidemics in parts of Asia and Africa. Hepatitis B is recognized as endemic in China and various other parts of Asia. Over one-third of the worlds population... hepatitis B. It needs to be phosphorylated to its triphosphate form before it is active. 3TC-triphosphate also inhibits cellular DNA polymerase 3D structure. A DNA polymerase is an enzyme that assists in DNA replication. Such enzymes catalyze the polymerization of deoxyribonucleotides alongside a DNA strand, which they read and use as a template. The newly polymerized molecule is complementary to the template strand and identical to the templates... DNA polymerase.

Lamivudine is administered orally, and it is rapidly absorbed with a bio-availability of over 80%. Some researche suggests that lamivudine can cross the The blood-brain barrier is a physical barrier between the blood vessels in the central nervous system, and the central nervous system itself. The barrier stops many substances from travelling across it. History The existence of such a barrier was first noticed in experiments by Paul Ehrlich in the late... blood-brain barrier. Lamivudine is often given in combination with Zidovudine (INN) or azidothymidine (abbreviated to AZT) is an antiretroviral drug, the first antiviral treatment to be approved for use against HIV. It is also sold under the names Retrovir and Retrovis, and as an ingredient in Combivir and Trizivir. History AZT was originally developed to treat cancer, at a... zidovudine, with which it is highly synergistic. Lamivudine treatment has been shown to restore zidovudine sensitivity of previously resistant HIV. Several mutagenicity tests show that lamivudine should not show In biology, a mutagen (Latin, literally origin of change) is an agent that changes the genetic information (usually DNA) of an organism and thus increases the number of mutations above the natural background level. Mutagens are usually chemical compounds or radiation. The Ames test is one method to determine how... mutagenic activity in therapeutical doses.

Lamivudine has been used for treatment of chronic hepatitis B at a lower dose that use in HIV. It improves the seroconversion of e-antigen positive hepatitis B and also improve histology staging of the liver. Long term use of lamivudine unfortunately leads to emergence of a resistant hepatitis B virus (YMDD) mutant. Despite this, lamivudine is still used widely as it is well tolerated.