After the road's junction with the M25 motorway at Waltham Cross, the road bypasses Cheshunt, Hoddesdon, Ware and Buntingford.
From Ware, the road used to pass through several Hertfordshire villages such as Wadesmill and Thundridge, but these are now bypassed by a 4-mile extension of the dual carriageway from London which opened in late 2004.
The A10 reappears to the north of Cambridge at the Milton Interchange of the A14 and heads north, bypassing Ely and Downham Market before reaching the coast at King's Lynn in Norfolk.