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The alpha-2B- receptor, also known as ADRA2B, is an alpha-2 adrenergic receptor, and also denotes the human gene encoding it.[1] Look up Hugo in Wiktionary, the free dictionary. ...
The Mouse Genome Informatics (MGI) website is run by The Jackson Laboratory. ...
HomoloGene[1], a tool of the National Center for Biotechnology Information (NCBI)[2], is a system for automated detection of homologs (similarity attributable to descent from a common ancestor) among the annotated genes of several completely sequenced eukaryotic genomes. ...
The Gene Ontology, or GO, project can be broadly split into two parts. ...
The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ...
Ensembl is a bioinformatics research project aiming to develop a software system which produces and maintains automatic annotation on selected eukaryotic genomes. It is run in a collaboration between the Wellcome Trust Sanger Institute and the European Bioinformatics Institute, an outstation of the European Molecular Biology Laboratory. ...
UniProt is the universal protein database, a central repository of protein data created by combining Swiss-Prot, TrEMBL and PIR. This makes it the worlds most comprehensive resource on protein information. ...
Medline is a comprehensive literature database of life sciences and biomedical information. ...
For other uses, see Gene (disambiguation). ...
Receptor Alpha-2-adrenergic receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Chemical structure of D-aspartic acid, a common amino acid neurotransmitter. ...
The sympathetic nervous system (SNS) is one half of the autonomic nervous system; the parasympathetic nervous system (PNS) is the other. ...
A diagram showing the CNS: 1. ...
Gene This gene encodes the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This gene contains no introns in either its coding or untranslated sequences.[1] Glutamic acid (Glu, E), is the protonated form of glutamate (the anion). ...
A Mu-opioid G protein-coupled receptor with its agonist Figure 1. ...
In biochemistry, a kinase is a type of enzyme that transfers phosphate groups from high-energy donor molecules, such as ATP, to specific target molecules (substrates); the process is termed phosphorylation. ...
Desensitization is a method to reduce or eliminate an organisms negative reaction to a substance or stimulus. ...
Basal metabolic rate (BMR) is the amount of energy expended while at rest in a neutrally temperate environment, in the post-absorptive state (meaning that the digestive system is inactive, which requires about twelve hours of fasting in humans). ...
Obesity is an excess storage of fat and can affect any mammal, such as the mouse on the left. ...
Diagram of the location of introns and exons within a gene. ...
The coding region of a gene is the portion of DNA that is transcribed into mRNA and translated into proteins. ...
See also Epinephrine Norepinephrine The adrenergic receptors (or adrenoceptors) are a class of G protein-coupled receptors that are targets of the catecholamines. ...
References Further reading - Lomasney JW, Lorenz W, Allen LF, et al. (1990). "Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2.". Proc. Natl. Acad. Sci. U.S.A. 87 (13): 5094-8. PMID 2164221.
- McClue SJ, Milligan G (1990). "The alpha 2B adrenergic receptor of undifferentiated neuroblastoma x glioma hybrid NG108-15 cells, interacts directly with the guanine nucleotide binding protein, Gi2.". FEBS Lett. 269 (2): 430-4. PMID 2169434.
- Weinshank RL, Zgombick JM, Macchi M, et al. (1990). "Cloning, expression, and pharmacological characterization of a human alpha 2B-adrenergic receptor.". Mol. Pharmacol. 38 (5): 681-8. PMID 2172775.
- Chang AC, Ho TF, Chang NC (1990). "In vitro amplification by polymerase chain reaction of a partial gene encoding the third subtype of alpha-2 adrenergic receptor in humans.". Biochem. Biophys. Res. Commun. 172 (2): 817-23. PMID 2173582.
- Regan JW, Kobilka TS, Yang-Feng TL, et al. (1988). "Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.". Proc. Natl. Acad. Sci. U.S.A. 85 (17): 6301-5. PMID 2842764.
- Petrash AC, Bylund DB (1986). "Alpha-2 adrenergic receptor subtypes indicated by [3H]yohimbine binding in human brain.". Life Sci. 38 (23): 2129-37. PMID 3012234.
- Klein U, Ramirez MT, Kobilka BK, von Zastrow M (1997). "A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B.". J. Biol. Chem. 272 (31): 19099-102. PMID 9235896.
- Okusa MD, Huang L, Momose-Hotokezaka A, et al. (1998). "Regulation of adenylyl cyclase in polarized renal epithelial cells by G protein-coupled receptors.". Am. J. Physiol. 273 (6 Pt 2): F883-91. PMID 9435676.
- Prezeau L, Richman JG, Edwards SW, Limbird LE (1999). "The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes.". J. Biol. Chem. 274 (19): 13462-9. PMID 10224112.
- Heinonen P, Koulu M, Pesonen U, et al. (1999). "Identification of a three-amino acid deletion in the alpha2B-adrenergic receptor that is associated with reduced basal metabolic rate in obese subjects.". J. Clin. Endocrinol. Metab. 84 (7): 2429-33. PMID 10404816.
- Hein L, Altman JD, Kobilka BK (2000). "Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission.". Nature 402 (6758): 181-4. doi:10.1038/46040. PMID 10647009.
- Small KM, Brown KM, Forbes SL, Liggett SB (2001). "Polymorphic deletion of three intracellular acidic residues of the alpha 2B-adrenergic receptor decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization.". J. Biol. Chem. 276 (7): 4917-22. doi:10.1074/jbc.M008118200. PMID 11056163.
- Snapir A, Mikkelsson J, Perola M, et al. (2003). "Variation in the alpha2B-adrenoceptor gene as a risk factor for prehospital fatal myocardial infarction and sudden cardiac death.". J. Am. Coll. Cardiol. 41 (2): 190-4. PMID 12535806.
- Sykiotis GP, Polyzogopoulou E, Georgopoulos NA, et al. (2004). "The alpha2B adrenergic receptor deletion/insertion polymorphism in morbid obesity.". Clin. Auton. Res. 13 (3): 203-7. doi:10.1007/s10286-003-0087-5. PMID 12822042.
- Chotani MA, Mitra S, Su BY, et al. (2004). "Regulation of alpha(2)-adrenoceptors in human vascular smooth muscle cells.". Am. J. Physiol. Heart Circ. Physiol. 286 (1): H59-67. doi:10.1152/ajpheart.00268.2003. PMID 12946937.
- Von Wowern F, Bengtsson K, Lindblad U, et al. (2004). "Functional variant in the (alpha)2B adrenoceptor gene, a positional candidate on chromosome 2, associates with hypertension.". Hypertension 43 (3): 592-7. doi:10.1161/01.HYP.0000116224.51189.80. PMID 14744925.
- Cayla C, Heinonen P, Viikari L, et al. (2004). "Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene.". Biochem. Pharmacol. 67 (3): 469-78. doi:10.1016/j.bcp.2003.09.029. PMID 15037199.
- Phares DA, Halverstadt AA, Shuldiner AR, et al. (2004). "Association between body fat response to exercise training and multilocus ADR genotypes.". Obes. Res. 12 (5): 807-15. PMID 15166301.
- Siitonen N, Lindström J, Eriksson J, et al. (2005). "Association between a deletion/insertion polymorphism in the alpha2B-adrenergic receptor gene and insulin secretion and Type 2 diabetes. The Finnish Diabetes Prevention Study.". Diabetologia 47 (8): 1416-24. doi:10.1007/s00125-004-1462-z. PMID 15309292.
- Belfer I, Buzas B, Hipp H, et al. (2005). "Haplotype-based analysis of alpha 2A, 2B, and 2C adrenergic receptor genes captures information on common functional loci at each gene.". J. Hum. Genet. 50 (1): 12-20. doi:10.1007/s10038-004-0211-y. PMID 15592690.
| Transmembrane receptor: G protein-coupled receptors | | Class A: Rhodopsin like | Acetylcholine (M5) - Adrenergic (α1A, α1B, α1D, α2A, α2B, α2C, β1, β2, β3) - Anaphylatoxin (C3a, C5a) - Angiotensin - Apelin - Bile acid - Bombesin (BRS3, GRPR, NMBR) - Bradykinin - Cannabinoid - Chemokine - Cholecystokinin - Dopamine - Eicosanoid (Prostaglandin) - Endothelin - Estrogen - Formyl peptide - Free fatty acid - FSH - Galanin - Ghrelin - Gonadotropin-releasing hormone - Histamine (H1, H2, H3, H4) - Kisspeptin - LHRH - Luteinizing hormone/choriogonadotropin - Lysophospholipid - MAS1 - Melanocortin (MC1R, MC2R) - MCHR - Melatonin - Motilin - Neuromedin (B, U) - Neuropeptide (B/W, FF, S, Y) - Neurotensin - Opioid (Delta, Kappa, Mu, Nociceptin, but not Sigma) - Olfactory (TAAR) - Orexin - Oxytocin - PAF - Prokineticin - Prolactin-releasing peptide - Protease-activated (PAR2, PAR3) - Purinergics (Adenosine, A1, P2Y, P2Y12) - Relaxin - Somatostatin - Serotonin, all but 5-HT3 (5-HT1, 5-HT2A) - SREB - Tachykinin (TACR1) - Thyrotropin - Thyrotropin-releasing hormone - Urotensin-II - Vasopressin (1A, 1B, 2) | | Class B: Secretin like | Calcitonin - Corticotropin-releasing hormone - EMR - Glucagon (GR, GIPR, GLP1R, GLP2R) - Growth hormone releasing hormone - Parathyroid hormone - Secretin - Vasoactive intestinal peptide | | Class C: Metabotropic glutamate / pheromone | Calcium-sensing receptor - GABA receptor (GABA B) - Glutamate receptor (Metabotropic glutamate) - RAIG - Taste receptors (TAS2R16, TAS2R38) | | Frizzled / Smoothened | Frizzled - Smoothened | |