NationMaster - Encyclopedia: AM404

AM404 also known as N-arachidonoylphenolamine is an active metabolite of Paracetamol (Acetaminophen) responsible for all or part of its analgesic action. Paracetamol (INN) (IPA: ) or acetaminophen (USAN), is a common analgesic and antipyretic drug that is used for the relief of fever, headaches, and other minor aches and pains. ... An analgesic (colloquially known as a painkiller) is any member of the diverse group of drugs used to relieve pain (achieve analgesia). ...

Pharmacology

AM404 has been noted as an endogenous cannabinoid reuptake inhibitor, preventing the transport of Anandamide and other related compounds back from the synaptic cleft, much in the same way that common SSRI antidepressants prevent the reuptake of serotonin. AM404 is also TRPV1 agonist, and also prevents cyclooxygenase COX-1 and COX-2 and prostaglandin synthesis. AM404 is thought to induce its analgesic action through its activity on the cannabinoid, COX and TRPV systems, all of which are present in pain and thermoregulatory pathways.^[1] Anandamide, also known as arachidonoylethanolamine or AEA, is a naturally occurring endogenous cannabinoid neurotransmitter found in the brain of animals, as well as other organs. ... SSRI is an acronym that stands for several things: It is a class of antidepressants called selective serotonin reuptake inhibitor SSRI also is used as the stock symbol for Silver Standard Resources Inc. ... The vanilloid receptor subtype 1 (TRPV1) is a nonselective ligand-gated cation channel that may be activated by a wide variety of exogenous and endogenous stimuli, including heat greater than 43Â°C, low pH, anandamide, and capsaicin. ... Cyclooxygenase (COX) is an enzyme (EC 1. ...

References

Category: Cannabinoids September 9 is the 252nd day of the year (253rd in leap years) in the Gregorian calendar. ... 2005 (MMV) was a common year starting on Saturday of the Gregorian calendar. ... A digital object identifier (or DOI) is a standard for persistently identifying a piece of intellectual property on a digital network and associating it with related data, the metadata, in a structured extensible way. ... For the Manfred Mann album, see 2006 (album). ... April 25 is the 115th day of the year in the Gregorian calendar (116th in leap years). ... Cannabinoids are a group of chemicals which activate the bodys cannabinoid receptors. ... Cannabidiol, also known as CBD, is a non-psychoactive cannabinoid found in the hemp plant Cannabis sativa. ... Cannabidivarine, also known as cannabidivarol or CBDV, is a non_psychoactive cannabinoid found in minor amounts in the hemp plant Cannabis sativa. ... Cannabinol, also known as CBN, is a non_psychoactive cannabinoid found in the hemp plant Cannabis sativa. ... Cannabigerol, also known as CBG, is a non-phychoactive Cannabinoid found in the Cannabis strain of plants. ... Cannabivarin, also known as cannabivarol or CBV, is a non-psychoactive cannabinoid found in minor amounts in the hemp plant Cannabis sativa. ... Cannabicyclol, also known as CBL, is a non-psychedelic cannabinoids found in the Cannabis species. ... Tetrahydrocannabinol, also known as THC, Î”9-THC, Î”9-tetrahydrocannabinol (delta-9-tetrahydrocannabinol), Î”Â¹-tetrahydrocannabinol (using an older numbering scheme), or dronabinol, is the main psychoactive substance found in a variety of plants; most abundantly so in the Cannabis plant. ... 11-hydroxy-THC is the primary active Î”9-THC metabolite. ... Tetrahydrocannabivarin, also known as tetrahydrocannabivarol, THCV, or THV, is a psychoactive cannabinoid found in minor amounts in the hemp plant Cannabis sativa. ... Tetrahydrocannabinol, also known as THC, Δ9-THC, Δ9-tetrahydrocannabinol, Δ1-tetrahydrocannabinol (using an older numbering scheme), or dronabinol, is the main psychoactive substance found in the hemp plant Cannabis sativa. ... Chemical structure of CP 55,940 CP 55,940, also written as CP55940, CP55,940, CP-55940, CP-55,940, and CP 55940, is a cannabinoid which mimics the effects of naturally occurring THC (the psychoactive compound found in marijuana). ... HU-210 HU-210 (CAS# 112830-95-2) is a synthetic cannabinoid that was discovered around 1988 in the group of Dr Raphael Mechoulam at the Hebrew University. ... WIN 55,212-2 is a chemical agent in the Cannabinoid family. ... Nabilone is a cannabinoid with therapeutic use as an antiemetic. ... Nabitan (Nabutam, Benzopyranoperidine) is a synthetic cannabinoid analog of dronabinol (Marinol). ... Levonantradol is a synthetic cannabinoid analog of dronabinol (Marinol). ... JWH-133 is a potent selective CB2 receptor agonist. ... URB597 urb597 In pre-clinical laboratory tests researchers found URB597 increased the production of endocannabinoids by blocking their degradation, resulting in measurable antidepressant effects. ... urb754 2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the central cannabinoid receptor (CB1) receptor. ... Rimonabant (SR141716) is an anorectic anti-obesity drug. ... AM251 is a CB1 cannabinoid receptor antagonist. ... THC phosphate ester is a water soluble derivative of THC, invented in 1978 in an attempt to get around the poor water solubility of THC and make it easier to inject for the purposes of animal research into its pharmacology and mechanism of action. ... THC acetate ester is a derivative of THC which has been found by the DEA as an apparent controlled substance analogue of THC. It was apparently made by extracting and purifying THC from cannabis plant material followed by reaction with acetic anhydride in an analogous manner to how heroin is... Parahexyl (Synhexyl, n-hexyl-Î”3THC) is a synthetic analogue of THC, which was invented in the 1950s during attempts to elucidate the structure of Î”9THC, the active component of cannabis. ... Ajulemic acid (IP-751) is a synthetic cannabinoid derivative of the non-psychoactive THC metabolite 11-carboxy-THC which shows useful analgesic and anti-inflammatory effects without causing a subjective high.[1] It is being developed for the treatment of neuropathic pain and inflammatory conditions such as arthritis. ... Anandamide, also known as arachidonoylethanolamine or AEA, is a naturally occurring endogenous cannabinoid neurotransmitter found in the brain of animals, as well as other organs. ... ...

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References

Pharmacology