Abdallat Davis Farrage syndrome is a syndrome consisting of disordered skin and hair pigmentation, progressive spastic paraparesis and peripheral neuropathy. It is also known as neurocutaneous syndrome, Abdallat Type. The syndrome is most likely inherited autosomal recessive. Peripheral neuropathy is the medical term for damage to nerves of the peripheral nervous system, which may be caused either by diseases of the nerve or from the side-effects of systemic illness. ... Phakomatoses (or neurocutaneous syndromes) are diseases that are caused by neurological disorders, and primarily result in lesions on the skin and the retina. ...

Symptoms

• Albinism (hair)
• Irregular decreased skin pigmentation
• Excessive freckling
• Insensitivity to pain
• Paraparesis/quadraparesis

Young woman with albinism from Malawi. ... Historical data for native populations collected by R. Biasutti prior to 1940. ...

References

• Abdallat A, Davis SM, Farrage J, McDonald WI (1980). Disordered pigmentation, spastic paraparesis and peripheral neuropathy in three siblings: a new neurocutaneous syndrome. J Neurol Neurosurg Psychiatry 43 (11): 962-6. PMID 7441281

External links

• Online Mendelian Inheritance in Man: Spastic paraplegia 23