Acceptable Daily Intake or ADI is a measure of a specific substance (usually a food additive) in food or drinking water that can be ingested over a lifetime without an appreciable health risk. ADIs are expressed by body mass, usually in milligrams per kilograms of body mass. Jump to: navigation, search It has been suggested that Colorings be merged into this article or section. ... Jump to: navigation, search Drinking water Drinking water is water that is intended to be drunk by humans. ...
This concept was first introduced in 1957 by the Council of Europe and later the Joint Expert Committee on Food Additives (JECFA) of the United Nations Food and Agricultural Organization and the World Health Organization. The Palace of Europe in Strasbourg The Council of Europe is an international organisation of 46 member states in the European region. ... Jump to: navigation, search The WHO flag: similar to the flag of the United Nations, augmented with the symbolic staff and serpent of Asklepios, Greek god of medicine and healing. ...
An ADI value is based on current research, with long-term studies on animals and observations of humans. First, a No Observable (Adverse) Effect Level, the amount of a substance that causes no toxic effects, is determined. Then, the NOEL (or NOAEL) is scaled by a safety factor, usually 100, to account for the lack of positive reliability on animal testing and possible differences in sensitivity in the human population. The ADI is usually given in mg per kg body weight per day. Note that the ADI is considered a safe intake level for the healthy adult of normal weight who consumes the average amount of the substance in question, not for small children or weak persons.
Acceptabledailyintake: Estimate of the amount of a substance in food or drinking water, expressed on a body mass basis (usually mg/kg body weight), which can be ingested daily over a lifetime by humans without appreciable health risk.
For calculation of the dailyintake per person, a standard body mass of 60 kg is used.
The acceptabledailyintake is normally used for food additives (tolerable dailyintake is used for contaminants).
Acceptabledailyintake: The daily dosage of a chemical which, during an entire lifetime, appears to be without appreciable risk on the basis of all the facts known at the time.
Knowledge of the "acceptabledailyintakes" of these substances would be useful in assessing consumer hazards that might arise from the use of the fumigant, particularly under conditions of abnormal pest infestation when the dose might have to be increased or the treatment repeated.
The acceptabledailyintake figures in the monographs that follow are intended to be of value as a check to ensure that tolerances are toxicologically acceptable.
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