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Encyclopedia > Acenocoumarol
Image:Acenocoumarol.png
Acenocoumarol
Systematic (IUPAC) name
 ?
Identifiers
CAS number 152-72-7
ATC code B01AA07
PubChem 9052
Chemical data
Formula  ?
Mol. weight 353.326
Pharmacokinetic data
Bioavailability  ?
Metabolism Liver
Half life 8-11 hrs.
Excretion  ?
Therapeutic considerations
Pregnancy cat.

? IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules . ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Santorio Santorio (1561-1636) in his steelyard balance, from Ars de statica medecina, first published 1614 Metabolism (from μεταβολισμος (metabolismos)) is the biochemical modification of chemical compounds in living organisms anggjgjhnd cell (b). ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother. ...

Legal status
Routes Oral

Acenocoumarol is a anticoagulant that functions as a vitamin K antagonist (like warfarin). The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... An anticoagulant is a substance that prevents coagulation; that is, it stops blood from clotting. ... Vitamin K denotes a group of 2-methilo-naphthoquinone derivatives. ... Warfarin (also known under the brand names of Coumadin®, Jantoven®, Marevan®, and Waran®) is an anticoagulant medication that is administered orally or, very rarely, by injection. ...


It is a derivative of coumarin and is marketed under the brand name Sintrom. Coumarin is a chemical compound found in many plants, notably in high concentration in the tonka bean, woodruff, and bison grass. ...


External links

  • DDB 29202
  • Cesar J, García-Avello A, Navarro J, Herraez M (2004). "Aging and oral anticoagulant therapy using acenocoumarol.". Blood Coagul Fibrinolysis 15 (8): 673-6. PMID 15613922.
  • Lengyel M (2004). "Warfarin or acenocoumarol is better in the anticoagulant treatment of chronic atrial fibrillation?". Orv Hetil 145 (52): 2619-21. PMID 15724697.
  • Ufer M (2005). "Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol.". Clin Pharmacokinet 44 (12): 1227-46. PMID 16372822.
  • Montes R, Ruiz de Gaona E, Martínez-González M, Alberca I, Hermida J (2006). "The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients.". Br J Haematol 133 (2): 183-7. PMID 16611310.


The Diseases Database is a free website that provides information about the relationships between medical conditions, symptoms, and medications. ...

Antithrombotics (thrombolytics, anticoagulants, and antiplatelet drugs) (B01) edit
Vitamin K antagonists:

Acenocoumarol, Clorindione, Dicumarol (Dicoumarol}, Diphenadione, Ethyl biscoumacetate, Phenprocoumon, Phenindione, Tioclomarol, Warfarin Thrombolytic drugs are used in medicine to dissolve blood clots in a procedure termed thrombolysis. ... An anticoagulant is a substance that prevents coagulation; that is, it stops blood from clotting. ... An antiplatelet drug is a member of a class of pharmaceuticals that decreases platelet aggregation and inhibits thrombus formation. ... A section of the Anatomical Therapeutic Chemical Classification System. ... Warfarin (also known under the brand names of Coumadin®, Jantoven®, Marevan®, and Waran®) is an anticoagulant medication that is administered orally or, very rarely, by injection. ...

Heparin group (Platelet
aggregation inhibitors):

Antithrombin III, Bemiparin, Dalteparin, Danaparoid, Enoxaparin, Heparin, Nadroparin, Parnaparin, Reviparin, Sulodexide, Tinzaparin Antithrombin is a small molecule that inactivates several enzymes of the coagulation system. ... Dalteparin is a low molecular weight heparin. ... Danaparoid sodium (Orgaran®) is an anticoagulant that works by inhibiting thrombin. ... Enoxaparin is a low molecular weight heparin manufactured by Sanofi-Aventis. ... Heparin as a drug is used as an injectable anticoagulant. ... In medicine, low molecular weight heparin (LMWH) is a class of medication used as an anticoagulant in diseases that feature thrombosis, as well as for prophylaxis in situations that lead to a high risk of thrombosis. ...

Other Platelet
aggregation inhibitors:

Abciximab, Acetylsalicylic acid (Aspirin), Aloxiprin, Beraprost, Ditazole, Carbasalate calcium, Cloricromen, Clopidogrel, Dipyridamole, Epoprostenol, Eptifibatide, Indobufen, Iloprost, Picotamide, Prasugrel, Ticlopidine, Tirofiban, Treprostinil, Triflusal Abciximab (previously known as c7E3 Fab), distributed by Eli Lilly under the trade name ReoPro®, is a platelet aggregation inhibitor mainly used during and after coronary artery procedures like angioplasty to prevent platelets from sticking together and causing thrombus (blood clot) formation within the coronary artery. ... A very old bottle of Aspirin Aspirin or acetylsalicylic acid is a drug in the family of salicylates, often used as an analgesic (against minor pains and aches), antipyretic (against fever), and anti-inflammatory. ... Clopidogrel (IPA: ) is a potent oral antiplatelet agent often used in the treatment of coronary artery disease, peripheral vascular disease, and cerebrovascular disease. ... Dipyridamole is a drug that inhibits platelet aggregation and causes vasodilation. ... Prostacyclin is a member of the family of lipid molecules known as eicosanoids. ... Eptifibatide (Integrilin®, Millennium Pharmaceuticals) is a anti-coagulant that selectively blocks the platelet glycoprotein IIb/IIIa receptor. ... iloprost, an inhalation solution, is sold under the name Ventavis® and is used to treat pulmonary arterial hypertension (PAH). ... Prasugrel is a novel platelet inhibitor developed by Sankyo and produced by Ube and currently under clinical development in cooperation with Eli Lilly for acute coronary syndromes planned for PCI. Categories: Biochemistry stubs | Pharmacology stubs ... Ticlopidine is a drug used for its antiplatelet action. ... // Basic Chemical and Pharmacological Information Tirofiban is a synthetic, nonpeptide inhibitor acting at glycoprotein-(GP)-receptors, type IIb/IIIa, in human thrombocytes. ...

Enzymes:

Alteplase, Ancrod, Anistreplase, Brinase, Drotrecogin alfa, Fibrinolysin, Protein C, Reteplase, Saruplase, Streptokinase, Tenecteplase, Urokinase In blood coagulation, tissue plasminogen activator (tPA) is an enzyme (EC 3. ... // Basic Chemical, Pharmacological, and Marketing Information Ancrod (also known under its former brand name Arwin® and recently Viprinex®) is an anticoagulant with a triple mode of action. ... Anistreplase is a thrombolytic drug. ... // Basic Chemical, Pharmacological and Marketing Data Drotrecogin alpha (activated) is a recombinant form of human activated protein C that has antithrombotic, antiinflammatory, and profibrinolytic properties. ... Protein C is a major physiological anticoagulant. ... Reteplase (Retavase®) is a thrombolytic drug, used to treat heart attacks by breaking up the clots that cause them. ... Streptokinase is an extracellular metallo-enzyme produced by beta-haemolytic streptococcus and is used as an effective and cheap clot-dissolving medication in some cases of myocardial infarction (heart attack) and pulmonary embolism. ... Urokinase, also called urokinase-type Plasminogen Activator (uPA) is an enzyme (EC 3. ...

Direct thrombin inhibitors:

Argatroban, Bivalirudin, Desirudin, Lepirudin, Melagatran, Ximelagatran Argatroban is a small molecule direct thrombin inhibitor. ... Basic Chemical and Pharmacological Properties Bivalirudin is an anticoagulant and acts as direct thrombin antagonist. ... Ximelagatran (Exanta®, H 376/95) is an anticoagulant that has been investigated extensively but is awaiting approval by the Food and Drug Administration (FDA). ... Ximelagatran (Exanta®, H 376/95) is an anticoagulant that has been investigated extensively but is awaiting approval by the Food and Drug Administration (FDA). ...

Other antithrombotics:

Dabigatran, Defibrotide, Dermatan sulfate, Fondaparinux, Rivaroxaban Dermatan sulfate is a glycosaminoglycan, formerly called a mucopolysaccharide, found mostly in skin, but also in blood vessels, heart valves, tendons, and lungs. ... Fondaparinux (Arixtra) is a medication that is an anticoagulant. ... Rivaroxaban (also known as BAY 59-7939) is an oral anticoagulant under development by Bayer. ...

Non-medicinal:

Citrate, EDTA, Oxalate An anticoagulant is a substance that prevents coagulation; that is, it stops blood from clotting. ... Chemical strucutre of citric acid. ... EDTA is the chemical compound ethylenediaminetetraacetic acid. ... The oxalate (also ethanedioate) ion is (COO)22− (oxalic acid minus two hydrogen ions). ...


  Results from FactBites:
 
Buy Sintrom - Acenocoumarol online without prescription, Order Sintrom - Acenocoumarol online, RealMedicals.com Online ... (1980 words)
Acenocoumarol passes into the breast milk of lactating mothers in quantities that are almost not detected; it also crosses the placental barrier.
Acenocoumarol is extensively metabolised, although the metabolites appear to be pharmacologically inactive in man. The elimination half-life of acenocoumarol from the plasma is 8 to 11 hours.
Acenocoumarol passes into the breast milk of lactating mothers, but in quantities so small that no undesirable effects on the infant are to be expected.
Acenocoumarol - Wikipedia, the free encyclopedia (194 words)
Acenocoumarol is a anticoagulant that functions as a vitamin K antagonist (like warfarin).
"Warfarin or acenocoumarol is better in the anticoagulant treatment of chronic atrial fibrillation?".
"The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients.".
  More results at FactBites »


 

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