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Encyclopedia > Achlorhydria
Achlorhydria
Classifications and external resources
Hydrogen chloride (major component of gastric acid)
ICD-10 K31.8
ICD-9 536.0
DiseasesDB 29513
eMedicine med/18 
MeSH D000126

Achlorhydria or hypochlorhydria is decreased production of gastric acid by the stomach. Image File history File links Download high-resolution version (1100x1017, 203 KB) File links The following pages on the English Wikipedia link to this file (pages on other projects are not listed): Hydrochloric acid Achlorhydria ... R-phrases , S-phrases , , , , Flash point non-flammable Supplementary data page Structure and properties n, εr, etc. ... Gastric acid is, together with several enzymes and the intrinsic factor, one of the main secretions of the stomach. ... The International Statistical Classification of Diseases and Related Health Problems (commonly known by the abbreviation ICD) is a detailed description of known diseases and injuries. ... The following codes are used with International Statistical Classification of Diseases and Related Health Problems. ... // K00-K93 - Diseases of the digestive system (K00-K14) Diseases of oral cavity, salivary glands and jaws (K00) Disorders of tooth development and eruption (K01) Embedded and impacted teeth (K02) Dental caries (K03) Other diseases of hard tissues of teeth (K04) Diseases of pulp and periapical tissues (K040) Pulpitis (K05... The International Statistical Classification of Diseases and Related Health Problems (commonly known by the abbreviation ICD) is a detailed description of known diseases and injuries. ... The following is a list of codes for International Statistical Classification of Diseases and Related Health Problems. ... The Diseases Database is a free website that provides information about the relationships between medical conditions, symptoms, and medications. ... eMedicine is an online clinical medical knowledge base that was founded in 1996. ... Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. ... Gastric acid is, together with several enzymes and the intrinsic factor, one of the main secretions of the stomach. ... In anatomy, the stomach (in ancient Greek στόμαχος) is an organ in the gastrointestinal tract used to digest food. ...

Contents

Causes

Its main cause is antibody production against parietal cells, the cells that normally produce the acid, and is therefore an autoimmune disorder. Schematic of antibody binding to an antigen An antibody or immunoglobulin is a large Y-shaped protein used by the immune system to identify and neutralize foreign objects like bacteria and viruses. ... Parietal cells (also called oxyntic cells) are cells located in the stomach epithelium. ... Autoimmune diseases arise from an overactive immune response of the body against substances and tissues normally present in the body. ...


It also occurs after long-term proton pump inhibitor therapy, or in patients with the rare disease mucolipidosis (type IV). Proton pump inhibitors are a group of drugs whose main action is pronounced and long-lasting reduction of gastric acid production. ... A rare disease has such a cow prevalence in a population that a doctor in a busy general practice would not expect to see more than one case a year. ... Mucolipidoses (ML) are a group of inherited metabolic diseases that affect the body’s ability to carry out the normal turnover of various materials within cells. ...


It can be part of pernicious anemia, atrophic gastritis, VIPomas or of carcinoid of the stomach. Pernicious anemia refers to a type of autoimmune anemia. ... Atrophic gastritis is a process of chronic inflammation of the stomach mucosa, leading to loss of gastric glandular cells and their eventual replacement by intestinal and fibrous tissues. ... A VIPoma is an endocrine tumor, usually originating in the pancreas, which produces a vasoactive intestinal peptide and is believed to cause profound cardiovascular and electrolyte changes with vasodilatory hypotension, watery diarrhea, hypokalemia, and dehydration. ... Carcinoid is a potentially malignant tumour that occurs in the mucosa of the lungs and digestive tract and potentially in other organs. ...


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Diagnosis

90% of all patients have detectable antibodies against the H+/K+ ATP-ase "proton pump". Gastric hydrogen potassium ATPase also know as H+/K+ ATPase // The gastric hydrogen potassium ATPase or H+/K+ ATPase is the proton pump of the stomach and as such is the enzyme primarily responsible for the acidification of the stomach contents (see gastric acid). ...


The diagnosis is made if the gastric pH remains high (>4.0) despite maximum pentagastrin stimulation. High gastrin levels are often detected. Pentagastrin is a synthetic polypeptide that has effects like gastrin when given parenterally. ... In humans, gastrin is a hormone that stimulates secretion of gastric acid by the stomach. ...


Presentation

Achlorhydria leads to bacterial overgrowth since the disinfectant qualities of the gastric acid are too weak. This can lead to infections (such as with Vibrio vulnificus). Phyla/Divisions Actinobacteria Aquificae Bacteroidetes/Chlorobi Chlamydiae/Verrucomicrobia Chloroflexi Chrysiogenetes Cyanobacteria Deferribacteres Deinococcus-Thermus Dictyoglomi Fibrobacteres/Acidobacteria Firmicutes Fusobacteria Gemmatimonadetes Nitrospirae Omnibacteria Planctomycetes Proteobacteria Spirochaetes Thermodesulfobacteria Thermomicrobia Thermotogae Bacteria (singular, bacterium) are a major group of living organisms. ... Disinfection The destruction of pathogenic and other kinds of microorganisms by physical or chemical means Disinfectants are chemical substances used to kill viruses and microbes (germs), such as bacteria and fungi. ... This article does not cite its references or sources. ...


Treatment

Treatment focuses on replacing vitamin B12 (which is poorly absorbed in the absence of intrinsic factor) and avoiding foods that may be have a high bacterial load. Cobalamin or vitamin B12 is a chemical compound that is also known as cyanocobalamine. ... Intrinsic factor is a glycoprotein produced by the parietal cells of the stomach. ...


Sources


  Results from FactBites:
 
eMedicine - Achlorhydria : Article Excerpt by Timothy R Koch (1076 words)
Achlorhydria is an important cause of hypergastrinemia, which can subsequently lead to the development of GI carcinoid tumors.
Achlorhydria has not been reported to affect men and women differently.
According to a report by Segal et al of 1590 patients, the incidence of achlorhydria was 19% in the fifth decade of life and 69% in the eighth decade of life.
Definition of achlorhydria - Merriam-Webster Online Dictionary (49 words)
Learn more about "achlorhydria" and related topics at Britannica.com
Find more about "achlorhydria" instantly with Live Search
See a map of "achlorhydria" in the Visual Thesaurus
  More results at FactBites »


 
 

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