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Encyclopedia > Adrenocorticotropic Hormone

Adrenocorticotropic hormone
Identifiers
Symbol POMC
Entrez 5443
HUGO 9201
OMIM 176830
RefSeq NM_000939
UniProt P01189
Other data
Locus Chr. 2 p23

Pronunciation (IPA): /əˈdrinoʊˌkɔrtɪkoʊˈtrɒpɪk ˈhɔrmoʊn, əˈdrinoʊˌkɔrtɪkoʊˈtroʊpɪk ˈhɔrmoʊn/ The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... Look up Hugo in Wiktionary, the free dictionary. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... National Center for Biotechnology Information logo The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... Short and long arms Chromosome. ... Chromosome 2 is one of the 23 pairs of chromosomes in humans. ... IPA may refer to: The International Phonetic Alphabet or India Pale Ale ...


Adrenocorticotropic hormone (ACTH or corticotropin) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. Peptides are the family of molecules formed from the linking, in a defined order, of various amino acids. ... Norepinephrine A hormone (from Greek όρμή - to set in motion) is a chemical messenger from one cell (or group of cells) to another. ... The pituitary gland, or hypophysis, is an endocrine gland about the size of a pea that sits in a small, bony cavity (sella turcica) covered by a dural fold (sellar diaphragm) at the base of the brain. ... It has been suggested that HTPA be merged into this article or section. ...

Contents

Production

ACTH synthesised from How are you today tyler? pro-opiomelanocortin (POMC) and secreted from corticotropes in the anterior lobe of the pituitary gland in response to the hormone corticotropin-releasing hormone (CRH) released by the hypothalamus. It can be also produced by cells of immune system (T cells, B cells and macrophages) as a response to stimuli which go along with stress (including CRH). Pro-opiomelanocortin (POMC) is a precursor polypeptide that is built of 241 amino acid residues. ... Corticotropes are cells in the anterior pituitary which produce adrenocorticotrophic hormone. ... The anterior pituitary (also called the adenohypophysis, from Greek adeno, gland; hypo, under; physis, growth; hence, glandular undergrowth) comprises the anterior lobe of the pituitary gland and is part of the endocrine system. ... The pituitary gland, or hypophysis, is an endocrine gland about the size of a pea that sits in a small, bony cavity (sella turcica) covered by a dural fold (sellar diaphragm) at the base of the brain. ... Corticotropin-releasing hormone (CRH), also called corticotropin-releasing factor (CRF) or corticoliberin, is a polypeptide hormone involved in the stress response. ... The hypothalamus links the nervous system to the endocrine system via the pituitary gland (hypophysis). ... T cells are a subset of lymphocytes that play a large role in the immune response. ... B cells are lymphocytes that play a large role in the humoral immune response (as opposed to the cell-mediated immune response). ... A macrophage of a mouse stretching its arms to engulf two particles, possibly pathogens Macrophages (Greek: big eaters, makros = long, phagein = eat) are white blood cells, more specifically phagocytes, acting in the nonspecific defense as well as the specific defense system of vertebrate animals. ...


POMC is cleaved into ACTH and β-lipotropin. γ-lipotropin and β-endorphin result from the cleavage of this β-lipotropin. Lipotropin is a pituitary hormone It comes in two forms: gamma lipotropin (γ-LPH) beta lipotropin (β-LPH) It is derived from proopiomelanocortin. ... Beta-endorphin is a neurotransmitter which is released from the anterior pituitary gland. ...


Structure

ACTH consists of 39 amino acids, the first 13 of which (counting from the N-terminus) may be cleaved to form α-melanocyte-stimulating hormone (α-MSH). (This common structure is one reason that patients with hypocortisolism or Addison's disease, in which ACTH levels are elevated, often present with excessively tanned skin.) Phenylalanine is one of the standard amino acids. ... The melanocyte-stimulating hormones (collectively referred to as MSH) are a class of peptide hormones produced by cells in the intermediate lobe of the pituitary gland. ... In medicine, adrenal insufficiency (or hypocortisolism) is the inability of the adrenal gland to produce adequate amounts of cortisol in response to stress. ... Addisons disease(also known as chronic adrenal insufficiency, hypocortisolism or hypocorticism) is a rare endocrine disorder in which the adrenal gland produces insufficient amounts of steroid hormones (glucocorticoids and often mineralocorticoids). ... In dermatology, hyperpigmentation is the darkening of an area of skin or nails caused by increased melanin. ...


After a short period of time, ACTH is cleaved into α-melanocyte-stimulating hormone (α-MSH) and CLIP, a peptide with unknown activity in humans. Melanocyte-stimulating hormone (MSH) is a peptide hormone produced by cells in the intermediate lobe of the pituitary gland. ...


Function

ACTH acts through the stimulation of cell surface ACTH receptors, which are primarily located on the adrenocortical cells. ACTH stimulates the cortex of the adrenal gland and boosts the synthesis of corticosteroids, mainly glucocorticoids but also sex steroids (androgens). The ACTH receptor is a type of melanocortin receptor (type 2) which is specific for ACTH. It is found in the zona fasciculata of the adrenal cortex and stimulates production of cortisol. ... Cortical part of the adrenal gland (on the pointer). ... In mammals, the adrenal glands (also known as suprarenal glands) are the triangle-shaped endocrine glands that sit on top of the kidneys; their name indicates that position (ad-, near or at + -renes, kidneys). They are chiefly responsible for regulating the stress response through the synthesis of corticosteroids and catecholamines... In physiology, corticosteroids are a class of steroid hormones that are produced in the adrenal cortex. ... Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger similar effects. ... Androgen is the generic term for any natural or synthetic compound, usually a steroid hormone, that stimulates or controls the development and maintenance of masculine characteristics in vertebrates by binding to androgen receptors. ...


ACTH is also related to the circadian rhythm in many organisms. A circadian rhythm is a roughly-24-hour cycle in the physiological processes of living beings, including plants, animals, fungi and cyanobacteria. ...


The half-life of ACTH in human blood is about 10 minutes. Half-Life For a quantity subject to exponential decay, the half-life is the time required for the quantity to fall to half of its initial value. ...


Synthetic ACTH

ACTH is available as a synthetic derivative in the form of cosyntropin (synthetic ACTH), tradename Cortrosyn®. ACTH is available as a synthetic derivative in the form of cosyntropin (synthetic ACTH), tradename Cortrosyn®. It contains the first 24 aminoacids of ACTH but retains full function. ...


Associated conditions

Addisons disease(also known as chronic adrenal insufficiency, hypocortisolism or hypocorticism) is a rare endocrine disorder in which the adrenal gland produces insufficient amounts of steroid hormones (glucocorticoids and often mineralocorticoids). ... Small cell carcinoma is a type of carcinoma usually associated with the lung, though it can be associated with other topographies, such as in cervical cancer. ... Adrenoleukodystrophy (ALD) is a degenerative disorder of myelin, a complex fatty neural tissue that insulates many nerves of the central and peripheral nervous systems. ... Congenital adrenal hyperplasia (CAH) refers to any of several autosomal recessive diseases resulting from defects in steps of the synthesis of cortisol from cholesterol by the adrenal glands. ... Wikipedia does not have an article with this exact name. ...

See also


  Results from FactBites:
 
Hormone - Wikipedia, the free encyclopedia (920 words)
The function of hormones is to serve as a signal to the target cells; the action of hormones is determined by the pattern of secretion and the signal transduction of the receiving tissue.
Hormone actions vary widely, but can include stimulation or inhibition of growth, induction or suppression of apoptosis (programmed cell death), activation or inhibition of the immune system, regulating metabolism and preparation for a new activity (e.g., fighting, fleeing, mating) or phase of life (e.g., puberty, caring for offspring, menopause).
A recently-identified class of hormones is that of the "Hunger Hormones" - ghrelin, orexin and PYY 3-36 - and "Satiety hormones" - e.g., leptin, obestatin.
Adrenocorticotropic hormone (ACTH; corticotropin) (from hormone) --  Encyclopædia Britannica (895 words)
Neurohypophysis and the polypeptide hormones of the hypothalamus
The hormones of vertebrates > Hormones of the pituitary gland > Adenohypophysis > Adrenocorticotropic hormone (ACTH; corticotropin)
After being released by neurosecretory cells of the brain, the thoracotropic hormone is carried by the blood to the prothoracic glands, where it stimulates the release of ecdysone in insects or crustecdysone in crustaceans, steroid hormones that initiate molting (the periodic shedding of the outer skeleton).
  More results at FactBites »

 

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