Non-automous Tuareg region, emcompassing the Tenere desert, the Ayr massif and the Azawagh plateau in Central-West Africa. The main city is Agadez. For other uses of the word, see Tuareg (disambiguation). ... Tenere is a desert region in the south central Sahara, Niger. ... Agadez is the largest city in northern Niger, lying in the Sahara and is the capital of Aïr, one of the traditional Tuareg federations. ...