McCune-Albright syndrome, described in 1937 by McCune and Albright, is a disease where two of the three following features are present: 1937 (MCMXXXVII) was a common year starting on Friday (link will take you to calendar). ... A disease is an abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person afflicted or those in contact with the person. ...

• (autonomous) endocrine hyperfunction
• Fibrous dysplasia
• Café-au-lait spots

The endocrine aspect of the disease can manifest itself as extremely premature puberty. The endocrine system is a control system of ductless endocrine glands that secrete chemical messengers called hormones that circulate within the body via the bloodstream to affect distant organs. ... Fibrous Dysplasia is a disease that causes growths or lesions in one or more bones of the human body. ... Puberty refers to the process of physical changes by which a childs body becomes an adult body capable of reproduction. ...

Genetically, there is a post-zygotic mutation of a gene involved in G-protein signalling, preventing downregulation of cAMP signalling. This article or section does not cite its references or sources. ... In biology, mutations are changes to the genetic material (usually DNA or RNA). ... This stylistic schematic diagram shows a gene in relation to the double helix structure of DNA and to a chromosome (right). ... G-proteins, short for guanine nucleotide binding proteins, are a family of proteins involved in second messenger cascades. ... Downregulation is the process by which a cell decreases the number of receptors to a given hormone or neurotransmitter to reduce its sensitivity to this molecule. ... Structure of cAMP Cyclic adenosine monophosphate (cAMP, cyclic AMP or 3-5-cyclic adenosine monophosphate) is a molecule that is important in many biological processes; it is derived from adenosine triphosphate (ATP). ...