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Encyclopedia > Alpha catenin
catenin (cadherin-associated protein), alpha 1, 102kDa
Identifiers
Symbol CTNNA1
HUGO 2509
Entrez 1495
OMIM 116805
RefSeq NM_001903
UniProt P35221
Other data
Locus Chr. 5 q31.2
catenin (cadherin-associated protein), alpha 2
Identifiers
Symbol CTNNA2
HUGO 2510
Entrez 1496
OMIM 114025
RefSeq NM_004389
UniProt P26232
Other data
Locus Chr. 2 p12-p11.1
catenin (cadherin-associated protein), alpha 3
Identifiers
Symbol CTNNA3
HUGO 2511
Entrez 29119
OMIM 607667
RefSeq NM_013266
UniProt Q9UI47
Other data
Locus Chr. 10 q21

Alpha-catenin was suggested to function as a linking protein between cadherins and actin-containing filaments of the cytoskeleton.[1] It has been reported that the actin binding proteins vinculin[2] and alpha-actinin[3] can bind to alpha-catenin. However, a protein complex including a cadherin, actin, beta-catenin and alpha-catenin has not been isolated. It has been suggested that alpha-catenin does not bind with high affinity to both actin filaments and the E-cadherin-beta-catenin complex at the same time.[4] It has been observed that when alpha-catenin is not in a molecular complex with beta-catenin, it dimerizes and functions to regulate actin filament assembly, possibly by competing with Arp2/3 protein.[5] Hugo is a masculine name. ... The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... Short and long arms Chromosome. ... Chromosome 5 is one of the 23 pairs of chromosomes in humans. ... Hugo is a masculine name. ... The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... Short and long arms Chromosome. ... Chromosome 2 is one of the 23 pairs of chromosomes in humans. ... Hugo is a masculine name. ... The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... Short and long arms Chromosome. ... Chromosome 10 is one of the 23 pairs of chromosomes in humans. ... The eukaryotic cytoskeleton. ... The adherent culture of BPAE cells featured in the digital image above was immunofluorescently labeled with primary anti-vinculin mouse monoclonal antibodies followed by goat anti-mouse Fab heavy and light chain fragments conjugated to Rhodamine Red-X. (www. ... Arp2/3 complex is a seven-subunit protein containing two Actin-Related Proteins, the eponymous Arp2 and Arp3. ...


The amino acid sequence of alpha-catenin has sequence similarity to that of vinculin.[6] The adherent culture of BPAE cells featured in the digital image above was immunofluorescently labeled with primary anti-vinculin mouse monoclonal antibodies followed by goat anti-mouse Fab heavy and light chain fragments conjugated to Rhodamine Red-X. (www. ...


Types

There are three human alpha-catenin genes:

  • alpha-1-catenin (also called alpha-E-catenin)
  • alpha-2-catenin (also called alpha-N-catenin)
  • alpha-3-catenin

External links

  • MeSH alpha+Catenin

Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. ...

References

  1. ^ Model of attachment of actin filaments to catenin-cadherin complexes. Figure 11.14 in The Cell: A Molecular Approach second edition by Geoffrey M. Cooper (2000) Published by Sinauer Associates, Inc. ISBN 0878932194 .
  2. ^ M. Watabe-Uchida, N. Uchida, Y. Imamura, A. Nagafuchi, K. Fujimoto, T. Uemura, S. Vermeulen, F. van Roy, E. D. Adamson and M. Takeichi. "alpha-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells" in Journal of Cell Biology (1998) Volume 142, pages 847-857. Entrez PubMed 9700171
  3. ^ K. A. Knudsen, A. P. Soler, K. R. Johnson and M. J. Wheelock "Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin" in Journal of Cell Biology (1995) Volume 130, pages 67-77. Entrez PubMed 7790378
  4. ^ S. Yamada, S. Pokutta, F. Drees, W. I. Weis and W. J. Nelson "Deconstructing the cadherin-catenin-actin complex" in Cell (2005) Volume 123, pages 889-901. Entrez PubMed 16325582
  5. ^ F. Drees, S. Pokutta, S. Yamada, W. J. Nelson and W. T. Weis. "Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly" in Cell (2005) Volume 123, pages 903-915. Entrez PubMed 16325583
  6. ^ A. Nagafuchi, M. Takeichi, and S. Tsukita. "The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression" in Cell (1991) Volume 65, pages 849-857. Entrez PubMed 1904011
v • d • e
Proteins of the cytoskeleton
Microfilaments Actins - Actin-binding proteins - Actinin - Arp2/3 complex - Cofilin - Destrin - Gelsolin - Myosins - Profilin - Tropomodulin - Troponin (T, C, I) - Tropomyosin - Wiskott-Aldrich syndrome protein
Intermediate filaments type 1 and 2 (Cytokeratin, type I, type II) - type 3 (Desmin, GFAP, Peripherin, Vimentin) - type 4 (Internexin, Nestin, Neurofilament) - type 5 (Lamin A, B)
Microtubules Dyneins - Kinesins - MAPs (Tau protein, Dynamin) - Tubulins - Stathmin
Catenins Alpha catenin - Beta catenin - Plakoglobin (gamma catenin) - Delta catenin
Nonhuman Major sperm proteins - Prokaryotic cytoskeleton (Crescentin, FtsZ, MreB)
Other APC - Dystrophin (Dystroglycan) - plakin (Desmoplakin, Plectin) - Spectrin - Talin - Utrophin - Vinculin

  Results from FactBites:
 
CTNNA2 - Alpha-2 catenin (1036 words)
Alpha E- and alpha N-catenin appeared to be co-localized in cell bodies of neurons in dorsal root ganglia, but alpha N-catenin was not expressed in cell bodies of neurons in the ventral horn that showed alpha E-catenin expression.
Furthermore, alpha N-catenin, a cadherin-associated protein, was found to occur at the roof plate of the mesencephalon and diencephalon, coinciding with Wnt-1 expression.
CTNNA2 is a homologue of Catna2 (Alpha-2 catenin) from Mus musculus.
Catenin antibodies (alpha-catenin, beta-catein, gamma-catenin) from RDI Divison of Fitzgerald Industries Intl (573 words)
Background: The catenins (alpha, beta and gamma) are cytoplasmic proteins which bind the highly conserved cytoplasmic tail of the E-Cadherin (also known as uvomorulin) molecule.
Alpha catenin was first identified as an E-cadherin-associated protein; however it also appears to be able to interact with other cadherin family members such as N-cadherin, and P-Cadherin.
Beta catenin was found to co-immunoprecipitate with the APC tumor suppressor protein in human colorectal tumor cell lines as well as in human kidney 293 cells.
  More results at FactBites »


 
 

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