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genome.gov | 1997 Release: First Parkinson's Gene. (1399 words) |
 | The alpha synuclein gene was an excellent candidate for being a Parkinson's disease gene because previous research had already shown that the amyloid plaques of Alzheimer's disease patients contained fragments of the alpha synuclein protein. |
| Alpha synuclein is actually a member of a group of similar synuclein genes in the human genome. |
| The alpha synuclein gene, and other similar genes known to exist in the human genome, are expected to help scientists decipher additional causes of Parkinson's and perhaps shed light on other devastating and common brain disorders. |
| Synuclein: 1999 (14523 words) |
| We conclude that up-regulation of synuclein in the target injury model is unlikely to mediate apoptotic death and propose that it may be due to a compensatory response in neurons destined to survive. |
| Pathogenic alpha-synuclein (alphaS) gene mutations occur in rare familial Parkinson's disease (PD) kindreds, and wild-type alphaS is a major component of Lewy bodies (LBs) in sporadic PD, dementia with LBs (DLB), and the LB variant of Alzheimer's disease, but beta-synuclein (betaS) and gamma-synuclein (gammaS) have not yet been implicated in neurological disorders. |
| Alpha synuclein has been identified as a potent and selective inhibitor of phospholipase D2, which produces phosphatidic acid (to which synuclein binds) and is believed to function in the partitioning of membranes between the cell surface and intracellular stores. |
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