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Encyclopedia > Alteplase

In blood coagulation, tissue plasminogen activator (tPA) is an enzyme (EC 3.4.21.68 (http://www.expasy.org/cgi-bin/nicezyme.pl?3.4.21.68)) that activates plasminogen, leading to fibrinolysis.


Recombinant tPA is used in diseases which feature blood clots, such as myocardial infarction and stroke. To be effective, tPA must be administered within the first three hours of the attack. Because of this, only about 3% of patients qualify for this treatment. Since tPA dissolves blood clots, there is risk of hemorrhage with its use.


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  Results from FactBites:
 
alteplase - Heart Disease and other cardiovascular conditions on MedicineNet.com (518 words)
DRUG CLASS AND MECHANISM: Alteplase is an injectable drug, given directly into a vein, that is used to treat conditions caused by arterial blood clots including heart attacks, strokes, chest pain at rest (unstable angina), blood clots in the lungs (pulmonary thrombosis), and other less common conditions involving blood clots.
Alteplase is an enzyme that occurs naturally in man and causes blood clots to dissolve.
PRESCRIBED FOR: Alteplase is used to treat persons with heart attacks (acute myocardial infarctions), strokes, chest pain at rest (unstable angina), blood clots in the lungs (pulmonary thrombosis or embolism), and other less common conditions involving blood clots.
MSN Encarta - Romania (1012 words)
  More results at FactBites »

 

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