In knot theory, a knot diagram is alternating if the crossings alternate under, over, under, over, as you travel along the strand. A link diagram is alternating if each strand has this property. A knot or link is alternating if it has an alternating diagram.
The simplest non-alternating prime knots have 8 crossings (and there are three such).
It is conjectured that as the crossing number increases, the percentage of knots that are alternating goes to 0 exponentially quickly.
Also, any reduced diagram of an alternating knot or link has the fewest possible crossings. This fact follows from the Tait flyping conjecture, which was proved by W. Menasco and Thistlethwaite in 1991 and 1993.
References
On Knots, Louis H. Kauffman, Princeton University Press, 1987. ISBN 0-691-08435-1.
Alternatinglinks end up having an important role in knot theory and 3-manifold theory, due to their complements having useful and interesting geometric and topological properties.