Ambrose Monk is a fictional character on the USA Network program "Monk". He is playerd by John Turturro. Ambrose is the brother of Adrian Monk, the main character. He is smarter than Adrian, but suffers from agoraphobia. He can be seen in at least two episodes and has a romantic interest in Natalie. He blames himself for Trudy's death because she was buying him cough medicine when her car was blown up. A “Monk” is a person who practices asceticism, the conditioning of mind and body in favor of the spirit. ... John Turturro (born February 28, 1957) is an American actor noted for his performances in To Live and Die in L.A. (1985), The Color of Money (1986), Five Corners (1987), Do the Right Thing (1989), and Men of Respect (1991). ... Adrian Monk is the protagonist of the television series Monk, portrayed by Tony Shalhoub. ... Agoraphobia is a form of anxiety disorder. ...