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Encyclopedia > Amelogenesis imperfecta

Amelogenesis Imperfecta is an inherited condition that presents abnormal formation of the enamel or external layer of teeth. Enamel is composed mostly of mineral, that is formed and regulated by the proteins in it. A.I. is due to the malfunction of the proteins in the enamel: ameloblastin, enamelin, tuftelin and amelogenin. People afflicted with Amelogenesis Imperfecta have teeth with abnormal colour: yellow, brown or grey. The teeth have a higher risk for cavities and are hypersensitive to temperature changes. This disorder can afflict any number of teeth. A.I. can be associated with specific syndromes of present alone. It is a genetic disorder because the instructions to form the proteins for the enamel are encoded in the genes and are passed from generation to generation. New mutations are also possible. Tooth enamel is the hardest and most mineralized substance of the body , and with dentin and cementum is one of the three major parts of the tooth. ... Types of teeth Molars are used for grinding up foods Carnassials are used for slicing food. ... Dental cavities, tooth decay, or caries is a disease of the teeth resulting in damage to tooth structure. ... A genetic disorder, or genetic disease is a disease caused by abnormal expression of one or more genes in a person causing a clinical phenotype. ...


References

-Enamel hypoplasia. Winter, G.B. Dent Clin North Am. 1975. 19(1):3-24
-Dental Enamel Formation and Its Impact on Clinical Dentistry. Simmer, J.P. et al. Journal of Dental Education. 2001. 65(9)


  Results from FactBites:
 
Amelogenesis imperfecta - Wikipedia, the free encyclopedia (650 words)
It is a genetic disorder because the instructions to form the proteins for the enamel are encoded in the genes and are passed from generation to generation.
Amelogenesis imperfecta presents with abnormal formation of the enamel or external layer of teeth.
"Phenotypic diversity and revision of the nomenclature for autosomal recessive amelogenesis imperfecta".
Amelogenesis imperfecta - Genetics Home Reference (742 words)
Mutations in the AMELX, ENAM, and MMP20 genes cause amelogenesis imperfecta.
About 5 percent of amelogenesis imperfecta cases are caused by mutations in the AMELX gene and are inherited in an X-linked pattern.
amelogenesis ; autosomal ; autosomal dominant ; autosomal recessive ; calcium ; cell ; chromosome ; congenital ; enamel ; gene ; hypoplasia ; incidence ; inheritance ; inheritance pattern ; mutation ; new gene mutation ; pattern of inheritance ; protein ; recessive ; sex chromosomes
  More results at FactBites »


 
 

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