Aminocaproic acid (marketed as Amicar) is a drug used to treat bleeding disorders. This page is a candidate to be moved to Wiktionary. ...
Mechanism of action
Aminocaproic acid works as an antifibrinolytic. It is a derivative of the amino acid lysine. It binds reversibly to the kringle domain of plasminogen and blocks the binding of plasminogen to fibrin and its activation to plasmin. Plasmin is an important degrading enzyme (EC 3. ... Fibrin is a protein involved in the clotting of blood. ...
Clinical use
Aminocaproic acid is used to treat excessive postoperative bleeding. It can be given orally or intravenously. One scenario where it may be useful is to treat bleeding after after dental extractions in patients with hemophilia, because the oral mucosa is rich in plasminogen activators. A meta-analysis found that lysine analogs like aminocaproic acid significantly reduced blood loss in patients undergoing coronary artery bypass grafting. Haemophilia or hemophilia is the name of any of several hereditary genetic illnesses that impair the bodys ability to control bleeding. ...
Side effects
Its side effects are mainly related to the gastrointestinal tract and include nausea, vomiting, abdominal pain, and diarrhea. The main risk associated with aminocaproic acid is the increased risk for thrombosis because of the inhibition of fibrinolysis. Thrombosis is the formation of a clot or thrombus inside a blood vessel, obstructing the flow of blood through the circulatory system. ...
Aminocaproicacid for the treatment of hemorrhaging caused by thrombolytic agents (e.g., alteplase, streptokinase, urokinase) is considered medically necessary.
Aminocaproicacid for the prevention of ocular hemorrhage secondary to ocular trauma is considered medically necessary.
Aminocaproicacid for the prevention or treatment of oral hemorrhage is considered medically appropriate for individuals with hemophilia prior to and following dental or oral surgery, and for other traumatic hemorrhage of the mouth and nasopharynx.
AminocaproicAcid Video No. 1 - Slow crystallization of amicar (aminocaproicacid) recorded with time-lapse cinemicrography under polarized illumination at a magnification of 100x with a playing time of 9.9 seconds.
AminocaproicAcid Video No. 2 - Crystallization of the drug amicar (aminocaproicacid) observed under polarized illumination at a magnification of 200x with a playing time of 7.5 seconds.
Amicar is the common name for the compound aminocaproicacid (6-aminohexanoic acid), a coagulant that is used medically to reduce or prevent bleeding.
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