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Encyclopedia > Amoxapine
chemical structure of amoxapine

Amoxapine (Asendin®; Asendis®; Defanyl®; Demolox®; Moxadil®) is a tricyclic antidepressant of the dibenzoxazepine class. It is used in the treatment of depression, panic disorders and bipolar disorder.


Amoxapine is a strong reuptake inhibitor of norepinephrine and weak reuptake reuptake inhibitor of serotonin. One of its major metabolite, 7-hydroxyamoxapine, has a dopamine receptor blocking effect.




  Results from FactBites:
 
MedicineHouse.com (1346 words)
Amoxapine is a metabolite of loxapine an antipsychotic agent.
Amoxapine has varying degrees of efficacy in different pain syndromes and may be better at relieving the burning, aching and dyesthetic component of neuropathic pain.
Amoxapine crosses the placenta and is excreted in breast milk.
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