Mesopotamia (Greek: Μεσοποταμία, translated from Old PersianMiyanrudan "the Land between the Rivers" or the Aramaic name Beth_Nahrin "two rivers") is a region of Southwest Asia. Strictly speaking, it is the alluvial plain lying between the Tigris and Iraq and Syria). More commonly, the term includes these river plains in totality as well as the surrounding lowland territories bounded by the Arabian Desert to the west and south, the Persian Gulf to the immediate south, the Zagros Mountains and the Caucasus mountains to the north.
Writings from Mesopotamia (Uruk, modern Warka) are the earliest written work in the world, giving Mesopotamia the reputation of being the "Cradle of Civilization".
Mesopotamia was settled by, and conquered by, numerous ancient civilizations, including the Sumerians, Akkadians, Babylonians, Assyrians and the Persian Empire. Peoples who threatened or invaded these lands include the Hittites and the Elamites. During the time of the Persian Empire of Sassanids this area was called Dil_i Iranshahr meaning "Iran's Heart" and the metropol Ctesiphon, the capital of Persia was situated in Mesopotamia.
These civilizations arose from earlier settlements and cultures which were among the first to make use of agriculture.
A DWELLER IN MESOPOTAMIA (http://fax.libs.uga.edu/DS49x2xM465D/), being the adventures of an official artist in the garden of Eden, by Donald Maxwell, 1921
Mesopotamia (Greek, “between the rivers”), one of the earliest centers of urban civilization, in the area of modern Iraq and eastern Syria between the Tigris and Euphrates rivers.
The river valleys and plains of Mesopotamia are open to attack from the rivers, the northern and eastern hills, and the Arabian Desert and Syrian steppe to the west.
Mesopotamia's richness always attracted its poorer neighbors, and its history is a pattern of infiltration and invasion.