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Local anesthetic - Wikipedia, the free encyclopedia (773 words) |
 | A local anesthetic is a drug that reversibly inhibits the propagation of signals along nerves. |
| Local anesthetic drugs act mainly by inhibiting sodium influx through sodium-specific ion channels in the neuronal cell membrane, in particular the so-called voltage-gated sodium channels. |
| Local anesthetic drugs bind more readily to "open" sodium channels, thus onset of neuronal blockade is faster in neurons that are rapidly firing. |
| EU School of Medicine - Division of Animal Resources :: Template Page (3399 words) |
| Balanced anesthesia is an important concept whereby a combination of drugs or agents, each in an amount sufficient to produce its major or desired effect to the optimum degree and keep its undesirable or unnecessary effects to a minimum. |
| Historically, injectable drugs have been popularly used for anesthesia of rabbits and rodents because they are inexpensive, avoid the technical demands of gas anesthesia, and have been generally safe, effective, and easy to administer. |
| Chloral hydrate is a controlled drug with a prolonged onset of action leading to an extended state of pre-anesthetic delirium that may be unpleasant for the animal and it can cause gastric ulcers and adynamic ileus. |
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