Anne became the wife of Richard Neville. Following the death of Anne's father, and subsequently that of her brother, Henry (who had been created a duke), Neville inherited the title and estates of the Earl of Warwick through her; strictly speaking, she was the 15th Countess of Warwick. Her older daughter, Isabel, married George, Duke of Clarence, the younger brother of King Edward IV of England. Her younger daughter, Anne Neville, was married to Edward of Westminster, the only son of King Henry VI. When Edward of Westminster was killed in the Battle of Tewkesbury, Anne was married to Richard of Gloucester, later King Richard III of England. Although their mother was still living, the husbands of the two Neville sisters fought over her inheritance, with Richard eventually coming out on top. Her grandson, Edward, eventually inherited the earldom.