Anne became the wife of Richard Neville. Following the death of Anne's father, and subsequently that of her brother, Henry (who had been created a duke), Neville inherited the title and estates of the Earl of Warwick through her; strictly speaking, she was the 15th Countess of Warwick. Her older daughter, Isabel, married George, Duke of Clarence, the younger brother of King Edward IV of England. Her younger daughter, Anne Neville, was married to Edward of Westminster, the only son of King Henry VI. When Edward of Westminster was killed in the Battle of Tewkesbury, Anne was married to Richard of Gloucester, later King Richard III of England. Although their mother was still living, the husbands of the two Neville sisters fought over her inheritance, with Richard eventually coming out on top. Her grandson, Edward, eventually inherited the earldom.
His son Guy deBeauchamp, 10th earl of Warwick (1278-1315), received grants of land in Scotland for his services at Falkirk, and in 1301 was one of the signatories of the letter to the pope denying the papal right to interfere in Scottish affairs.
His son, Thomas deBeauchamp, 11th earl (1313-1369), was marshal of England in 1344, and of the English army in France in 1346.
She was succeeded in 1493 in the earldom by her grandson Edward Plantagenet, 18th earl of Warwick (1475-1499), son of the duke of Clarence, and therefore the Yorkist heir to the crown.
Warwick married Lady AnnedeBeauchamp, the sister of HenrydeBeauchamp, 1st Duke of Warwick, 14th Earl of Warwick.
Warwick now planned to consolidate his alliance with Louis XI of France by helping France to invade Burgundy, for which King Louis promised him the reward of the Burgundian territories of Zeeland and Holland.
By the time Margaret and her supporters were ready to join Warwick from France, Warwick (along with his brother and chief supporter Montagu) had been defeated and killed by the returning Edward IV at the Battle of Barnet.