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The Anomeric Effect (2865 words) |
 | The anomeric effect was initially defined as the preference for an electronegative substituent, at the anomeric carbon in a carbohydrate, to be in an axial rather than equatorial orientation. |
| It is noteworthy to mention that the conformation of the substituent at the anomeric carbon must be such that a lone pair orbital is anti-periplanar to the antibonding orbital of the bond between the anomeric carbon and the ring oxygen. |
| The bond between the electronegative atom X and the anomeric carbon A can be either synclinal (axial in a ring system) to the bond between the atom which possesses lone pairs (the heteroatom in a ring system) and the R group (a bridge atom in the ring system) or anti-periplanar (equatorial in a ring system). |
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