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Central nervous system injury treatment with opiate-receptor antagonist - Patent 5025018 (1280 words) |
 | The present invention involves methods of inducing opiate-receptor antagonistic activity in a patient suffering from ischemic or traumatic central nervous system injury by administering to said patient an effective amount of an opiate-receptor antagonist having enhanced activity at the kappa-opiate receptor suitable to permit the induction of opiate-receptor antogonistic activity. |
| A method of inducing kappa-opiate-receptor antagonistic activity in a patient suffering from ischemic or traumatic central nervous system injury which comprises administering to said patient an effective amount of a kappa-opiate-receptor antagonist suitable to permit the induction of kappa-opiate receptor antagonistic activity. |
| The present invention provides a method of inducing opiate-receptor antagonistic activity in a patient suffering from ischemic or traumatic central nervous system injury which comprises administering to said patient an effective amount of an opiate-receptor antagonist having enhanced activity at the kappa-opiate receptor suitable to permit the induction of opiate-receptor antagonistic activity. |
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Antagonist | Encyclopedia of Drugs and Addictive Behavior (343 words) |
| As the concentration of antagonist is increased, the binding of the agonist is progressively inhibited, resulting in a decrease in the physiological response. |
| A competitive antagonist, therefore, shifts the dose-response relationship for the agonist to the right, so that an increased concentration of the agonist in the presence of a competitive antagonist is required to produce the same biological response observed in the absence of the antagonist. |
| In this case, the binding of the antagonist to the receptor (its affinity) may be so strong that the receptor is unavailable for binding by the agonist. |
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