Antigen presentation is a process in the body's immune system by which macrophages, dendritic cells and leukocytes capture antigens and then carry those antigens to T-cells. Once a T-cell has been attuned to an antigen it will then circulate throughout the bloodstream, seeking out that antigen and destroying it. The immune system is composed of a complex constellation of cells, organs and tissues, arranged in an elaborate and dynamic communications network and equipped to optimize the response against invasion by pathogenic organisms. ... Macrophages (Greek: big eaters) are cells found in tissues that are responsible for phagocytosis of pathogens, dead cells and cellular debris. ... Dendritic cells (DC) are immune cells and form part of the mammal immune system. ... White Blood Cells is also the name of a White Stripes album. ... An antigen is a substance that stimulates an immune response, especially the production of antibodies. ... T cells are a subset of lymphocytes that play a large role in the immune response. ...
T cells recognize foreign pathogens in the body when fragments of the pathogen, antigenic epitopes, are 'presented' to them by specific molecules, termed major histocompatibility complexes (MHC), on the surface of infected or malignant cells.
Antigen Express technology focuses on modulating immune responses mediated by T helper (Th) cells, a class of lymphocytes that plays a multifaceted role in the immune system, both enhancing and suppressing immune responses.
The heart of the Antigen Express technology platform is the Ii (invariant chain) protein, which regulates antigenpresentation by MHC class II molecules and consequent T helper cell activation.
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