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Founded near the end of the 4th century BC by Seleucus I Nicator, one of Alexander the Great's generals, Antioch was destined to rival Alexandria as the chief city of the nearer East and to be the cradle of gentile Christianity.
Antioch became the capital and court-city of the western Seleucid empire under Antiochus I, its counterpart in the east being Seleucia on the Tigris; but its paramount importance dates from the battle of Ancyra (240 BC), which shifted the Seleucid centre of gravity from Asia Minor, and led indirectly to the rise of Pergamum.
Antioch gave its name to a certain school of Christian thought, distinguished by literal interpretation of the Scriptures and insistence on the human limitations of Jesus.
With Bohemund left behind in Antioch; with the possession of the Holy Lance to give him prestige; and with the wealth which he had at his disposal, the count of Provence now definitely began to figure as the leader of the Crusade.
As at Antioch, so at Jerusalem, he fell into strife with the new ruler; and it was only with difficulty that Godfrey was able to secure from him the possession of the Tower of David, which he had originally occupied.
In 1102 he came by sea from Constantinople to Antioch, where he was imprisoned by Tancred, regent of Antioch during the captivity of Bohemund, and only dismissed upon promising not to attempt any conquests in the country between Antioch and Acre.