Aprotinin (Trasylol®, Bayer) is an injection used to reduce bleeding and clotting during heart surgery. Aprotinin is a chemical in the body responsible for breaking down certain proteins in the blood which prevents blood clot formation and thus increase bleeding. Thus, aprotinin limits bleeding by eliminating the breakdown of clots, and can be used to prevent excessive blood loss during surgery. Bayer AG (German pronunciation BYE-er, in US usually pronounced BAY-er) (NYSE: BAY, TYO: 4863 ) is a German chemical and pharmaceutical company founded in 1863. ... Injection has multiple meanings: In mathematics, the term injection refers to an injective function. ... Minor traumatic bleeding from the head Bleeding is the loss of blood from the body. ... Coagulation is the thickening or congealing of any liquid into solid clots. ... Cardiac surgery is surgery on the heart, typically to correct congenital heart disease or the complications of ischaemic heart disease or valve problems caused by endocarditis. ...
Side effects
Aprotinin doubles a patient's risk of kidney failure, heart failure, and heart attack in heart bypass patients as well as the number of patients needing kidney dialysis. A research by Ischemia Research and Education Foundation and the McSPI Research Group, led by Dennis T. Mangano, advises replacing Aprotinin by other, safer generic drugs. Renal failure is when the kidneys fail to function properly. ... A myocardial infarction occurs when an atherosclerotic plaque slowly builds up in the inner lining of a coronary artery and then suddenly ruptures, totally occluding the artery and preventing blood flow downstream. ... A coronary artery bypass graft (CABG) or heart bypass is a surgical procedure performed in patients with coronary artery disease (see atherosclerosis) for the relief of angina and possible improved heart muscle function. ... In medicine, dialysis is a type of renal replacement therapy which is used to provide an artificial replacement for lost kidney function in renal failure. ...
Aprotinin is a potent natural inhibitor of plasma protease obtained from bovine lung tissue.
Aprotinin may block the conversion of kininogen to the inflammatory mediator bradykinin, as well as inhibit the activation of C1 of the complement system, and the whole body inflammatory response is attenuated (6).
Aprotinin prolongs the celite activated ACT by different mechanism of heparin, and may lead to an overestimation of the degree of anticoagulation.
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