Arachnoid granulations (and arachnoid villi) are small protrusions of the arachnoid (the thin second layer covering the brain) through the dura (the thick outer layer). They protrude into the venous sinuses of the brain, and allow cerebrospinal fluid (CSF) to exit the brain, and enter the blood stream. Occasionally, they are referred to by their old name: Pacchioni's granulations or pacchionian bodies, named after Italian anatomist Antonio Pacchioni.

Most large granulations lie along the superior sagittal sinus, a large venous space running from front to back along the centre of the head (on the inside of the skull). They are, however present, along other dural sinuses as well. Smaller granulations are called villi, large calcified ones are referred to as pacchionian bodies.

The arachnoid granulations act as one-way valves. Normally the pressure of the CSF is higher than that of the venous system, so CSF flows through the villi and granulations into the blood. If the pressure is reversed for some reason, fluid willl not pass back into the subarachnoid space (of the brain). The reason for this is not known. It has been suggested that the endothelial cells of the venous sinus create vacuoles of CSF, which move through the cell and out into the blood.