Aromatase inhibitors (AI) are a class of In J. R. R. Tolkiens world of Middle-earth, the Drúedain, also known as Drûg, Woses, Wild Men of the Woods and Púkel-men, were a strange race of Men which was counted amongst the Edain. The Drûg lived among the Second House of Men... drugs used in the treatment of Breast cancer is cancer of breast tissue. Worldwide, it is the most common form of cancer in females, affecting approximately 10% of all women at some stage of their life in the Western world. Although significant efforts are made to achieve early detection and effective treatment, about 20% of all... breast cancer in post- Menopause (also known as the Change of life or climacteric) is a stage of the human female reproductive cycle that occurs as the ovaries stop producing estrogen, causing the reproductive system to gradually shut down. As the body adapts to the changing levels of natural hormones, vasomotor symptoms such as... menopausal women. Aromatase inhibitors work by inhibiting the action of the enzyme aromatase which converts androgens into estrogens by a process called aromatization. In contrast to pre-menopausal women, in whom most of the estrogen in produced in the ovaries, in post-menopausal women most of the body's estrogen is produced in the In mammals, the adrenal glands are the triangle-shaped endocrine glands that sit atop the kidneys. They are chiefly responsible for regulating the stress response through the synthesis of corticosteroids and catecholamines, including cortisol and adrenalin. Overview Anatomically, the adrenal gland is situated on the anteriosuperior aspect of the kidney... adrenal gland from the conversion of androgens. Because some breast cancers respond to estrogen, lowering the estrogen level in post-menopausal women using aromatase inhibitors has been proven to be effective in breast cancer treatment. Aromatase inhibitors are not useful in women who are pre-menopausal, however, because AIs do not inhibit ovarian estrogen production.

Investigations are ongoing to look for other applications. Increasingly, for example, researchers are using aromatase inhibitors to stimulate ovulation (in a manner similar to, but not exactly the same as, Categories: Stub | Selective estrogen receptor modulators ... clomiphene citrate).