After his father Yoshimochi retired, Yoshikazu became Seii Taishogun but died young years afterwards. He was succeded 4 years later by his uncle, the 6th shogun Ashikaga Yoshinori in 1429.
For reasons that are unclear, possibly because Ashikaga was the de facto leader of the powerless Minamoto clan, while the HÅjÅ clan were from the Taira clan the Minamoto had previously defeated, Ashikaga turned against the Kamakura bakufu, and fought on behalf of the Imperial court.
When the last effective Ashikagashogun Yoshiteru was assassinated in 1565, an ambitious daimyo, Oda Nobunaga, seized the opportunity and installed Yoshiteru's brother Ashikaga Yoshiaki as the 15th Ashikagashogun.
The Ashikaga family survived the 16th century, and a branch of it became the daimyo family of the Kitsuregawa domain.