AstraZeneca PLC

Type	Public LSE, NYSE and OMX: AZN
Founded	6 April 1999 by merger
Location	Corporate HQ in London, England R&D HQ in Södertälje, Sweden
Key people	Sir Tom McKillop CEO David Brennan Vice President, North America and CEO-designate Louis Schweitzer Chairman John Symonds CFO John Patterson Director, Drug Development
Industry	{{{industry}}}
Products	Pharmaceutical products for humans
Revenue	{{{revenue}}}
Website	www.astrazeneca.com

AstraZeneca PLC^[1], is a large Anglo-Swedish pharmaceutical company formed on 6 April 1999 by the merger of Swedish Astra AB and British Zeneca Group PLC. Zeneca was part of Imperial Chemical Industries prior to a demerger in 1993.^[2][3] AstraZeneca develops, manufactures, and sells pharmaceuticals to treat disorders in the gastrointestinal, cardiac and vascular, neurological and psychiatric, infection, respiratory, pathological inflammation and oncology areas. Image File history File links cropped version of AstraZeneca International logo found at http://www. ... The Source by Greyworld, in the new LSE building The London Stock Exchange (abbreviated LSE) is a stock exchange located in London. ... New York Stock Exchange (June 2003) The New York Stock Exchange (NYSE) is the second largest stock exchange in the world. ... OMX is the stock symbol for OfficeMax. ... April 6 is the 96th day of the year in the Gregorian calendar (97th in leap years). ... 1999 is a common year starting on Friday of the Common Era, and was designated the International Year of Older Persons by the United Nations. ... London — containing the City of London — is the capital of the United Kingdom and of England and a major world city. With over seven million inhabitants (Londoners) in Greater London area, it is amongst the most densely populated areas in Western Europe. ... For the tax agency in the UK of the same name , see HM Revenue and Customs. ... The front page of the English Wikipedia website. ... A pharmaceutical company (or drug company) is a company licensed to discover, develop, market and distribute drugs. ... April 6 is the 96th day of the year in the Gregorian calendar (97th in leap years). ... 1999 is a common year starting on Friday of the Common Era, and was designated the International Year of Older Persons by the United Nations. ... ICIs logo. ... Gastroenterology or Gastrology might be better described as the field of digestive diseases, which are traditionally separated by anatomic or functional category. ... Cardiology is the branch of medicine dealing with disorders of the heart and blood vessels. ... The arterial system The blood vessels are part of the circulatory system and function to transport blood throughout the body. ... Neurology is the branch of medicine dealing with the nervous system and its disorders. ... Psychiatry is the branch of medicine that diagnoses, treats, and studies mental illness and behavioral conditions. ... In medicine, infectious disease or communicable disease is disease caused by a biological agent (e. ... In medicine, pulmonology is the specialty that deals with diseases of the lungs and the respiratory tract. ... Inflammation is the first response of the immune system to infection or irritation and may be referred to as the innate cascade. ... Please refer to cancer for the biology of malignant disease, as well as a list of malignant diseases. ...

Sales in 2003 totalled $18.8 billion, with a profit before tax of $4.2 billion. Total R&D spending was $3.5 billion. The corporate headquarters are in London, UK, the research and development (R&D) headquarters are in Södertälje, Sweden. Major R&D centres are located on three continents in the United States, United Kingdom, Sweden, and India. The phrase research and development (also R and D or R&D) has a special commercial significance apart from its conventional coupling of research and technological development. ... St. ... Södertälje [søːdə˘ʈɛljÉ™] is a Municipality in Stockholm County, in central Sweden. ...

The current chief executive of AstraZeneca is Sir Tom McKillop. It has been announced that McKillop will be retiring from the CEO role as of 1st Jan 2006 to be replaced by David Brennan.^[4] Sir. ...

Profiles

• Yahoo profile

Diversity

AstraZeneca is one of the 100 Best Companies for Working Mothers in 2004 according to Working Mothers magazine.^[5]

Products

AstraZeneca specialises in prescription medicines to fight disease in the several therapeutic areas. Year-on sales information can be found through AstraZeneca annual reports. The following is a list of key products as found on the AstraZeneca US website, retrieved 2005-03-27.

• Gastrointestinal
  • Entocort
  • Losec/Prilosec
  • Nexium (purified stereoisomer of Losec)

• Cardiovascular
  • Atacand
  • Crestor (2003 launch)
  • Exanta (2004 launch; not approved in the United States)
  • Imdur
  • Indural
  • Lexxel
  • Logimax
  • Nif-Ten
  • Plendil
  • Ramace
  • Seloken ZOK/Toprol-XL (#1 beta blocker by sales globally in 2004)
  • Tenoretic
  • Tenormin
  • Unimax
  • Zestoretic
  • Zestril

• Respiratory and Inflammation
  • Accolate
  • Bambec
  • Bricanyl
  • Oxis
  • Pulmicort
  • Rhinocort
  • Symbicort

• Oncology
  • Arimidex
  • Casodex
  • Faslodex
  • Iressa
  • Nolvadex
  • Tomudex
  • Zoladex
  • in development
    • Zactima (Phase III clinical trial - Press release)

• Neuroscience
  • Indural
  • Mysoline (handed over to Acorus Therapeutics Ltd. in July of 2004)
  • Seroquel
  • Vivalan
  • Zomig
  • Anaesthetics
    • Carbocaine
    • Citanest
    • Diprivan
    • EMLA (mixture of Lidocaine and Prilocaine)
    • Marcaine/Sensorcaine
    • Naropin
    • Xylocaine

• Infection
  • Apatef/Cefotan
  • Merrem/Meronem

For the Physics term GUT, please refer to Grand unification theory The gastrointestinal or digestive tract, also referred to as the GI tract or the alimentary canal or the gut, is the system of organs within multicellular animals which takes in food, digests it to extract energy and nutrients, and... Budesonide is a corticosteroid for the treatment of asthma, non-infectious rhinitis (including hay fever and other allergies), and for treatment and prevention of nasal polyposis. ... Omeprazole is a proton pump inhibitor used in the treatment of dyspepsia, peptic ulcer disease (PUD), GORD and Zollinger-Ellison syndrome. ... Esomeprazole is a proton pump inhibitor used in the treatment of dyspepsia, peptic ulcer disease (PUD), GERD and Zollinger-Ellison syndrome. ... Stereoisomerism is the arrangement of atoms in molecules whose connectivity remains the same but their arrangement in space is different in each isomer. ... The circulatory system or cardiovascular system is the organ system which circulates blood around the body of most animals. ... Candesartan (kan-de-SAR-tan) belongs to the class of medicines called angiotensin II inhibitors. ... Categories: Medicine stubs | Hypolipidemic agents ... Ximelagatran (Exanta®, H 376/95) is an anticoagulant that has been investigated extensively but is awaiting approval by the Food and Drug Administration (FDA). ... Isosorbide mononitrate is a drug used principally in the treatment of angina pectoris and acts by dilating the blood vessels so as to reduce the blood pressure. ... Felodipine is a calcium channel blocker (calcium antagonist), a drug used to control hypertension (high blood pressure). ... Metoprolol is a beta blocker drug used in treatment of several diseases of the cardiovascular system. ... Beta blockers or beta-adrenergic blocking agents are a class of drugs used to treat a variety of cardiovascular conditions and some other diseases. ... Lisinopril (lye-SIH-no-pril) is an angiotensin converting enzyme (ACE) inhibitor for hypertension, congestive heart failure, acute myocardial infarction, and renal and retinal complications of diabetes. ... Respiration can refer to: Cellular respiration, which is the use of oxygen in the metabolism of organic molecules. ... Inflammation is the first response of the immune system to infection or irritation and may be referred to as the innate cascade. ... Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma. ... The drug Terbutaline (trade names Brethine, Bricanyl, or Brethaire) is a β2-adrenergic receptor agonist, used as a fast-acting bronchodilator and to delay premature labour as a tocolytic. ... Budesonide is a corticosteroid for the treatment of asthma, non-infectious rhinitis (including hay fever and other allergies), and for treatment and prevention of nasal polyposis. ... Budesonide is a corticosteroid for the treatment of asthma, non-infectious rhinitis (including hay fever and other allergies), and for treatment and prevention of nasal polyposis. ... Symbicort is an inhaled treatment for asthma and COPD, marketed by AstraZeneca. ... Please refer to cancer for the biology of malignant disease, as well as a list of malignant diseases. ... Anastrozole is a drug used to treat advanced breast cancer in post-menopausal women. ... Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. ... Fulvestrant is a drug treatment of hormone receptor positive metastatic breast cancer in post-menopausal women with disease progression following anti-estrogen therapy. ... Gefitinib is a new chemotherapeutic drug used in the treatment of certain types of cancer. ... Tamoxifen is an oral selective estrogen receptor modulator which is used in breast cancer, and is currently the worlds largest selling breast cancer treatment. ... Goserelin is an injectable luteinising hormone-releasing hormone analogue (LHRHa). ... In medicine, a clinical trial (synonyms: clinical studies, research protocols, medical research) is a research study. ... Neuroscience is a field of study which deals with the structure, function, development, genetics, biochemistry, physiology, pharmacology and pathology of the nervous system. ... Primidone, is an anticonvulsant of the pyrimidinedione[7] class whose active metabolites, phenobarbital (minor) and phenylethylmalonamide (PEMA) (major), are also anticonvulsants. ... July is the seventh month of the year in the Gregorian Calendar and one of seven Gregorian months with the length of 31 days. ... 2004 is a leap year starting on Thursday of the Gregorian calendar. ... Quetiapine (kwe-TYE-a-peen), marketed by AstraZeneca with the brand name Seroquel, is one of the atypical antipsychotics. ... ... Zolmitriptan is an oral, selective 5-hydroxytryptamine 1B/1D (5-HT 1B/1D ) receptor agonist, or triptan, for acute treatment of migraine attacks with or without aura. ... Anesthesia (AE), also anaesthesia (BE), is the process of blocking the perception of pain and other sensations. ... Propofol is an intravenous anesthetic agent used for the induction of general anesthesia in adult patients and pediatric patients older than 3 years of age; maintenance of general anesthesia in adult patients and pediatric patients older than 2 months of age; and intensive care unit (ICU) sedation for intubated, mechanically... EMLA Cream is a topical local anesthetic, consisting of lidocaine 2. ... Ropivacaine (1-propyl-2’,6’-pipecoloxylidide; Naropin®) is a long-acting local anesthetic given by injection to reduce the sensation of pain. ... Lidocaine (INN) or lignocaine (former BAN) is a popular local anesthetic often used in dentistry or topically. ... An infection is the detrimental colonization of a host organism by a foreign species. ... Cefotetan is an injectable antibiotic of the cephamycin type for prophylaxis and treatment of bacterial infections. ... Meropenem is an ultra-broad spectrum injectable antibiotic for a wide variety of serious infections, including meningitis and pneumonia. ...

Controversy over Nexium

Nexium, the successor to Prilosec, has according to some commentators "become a symbol of everything that is wrong with the pharmaceutical industry".^[6] Esomeprazole is a proton pump inhibitor used in the treatment of dyspepsia, peptic ulcer disease (PUD), GERD and Zollinger-Ellison syndrome. ... Omeprazole is a proton pump inhibitor used in the treatment of dyspepsia, peptic ulcer disease (PUD), GORD and Zollinger-Ellison syndrome. ...

Collaborations and alliances

references in this section appear here rather than as endnotes and should be press releases from one or more of the partners; there should be only one entry for each collaboration and only one informational reference in order to maintain a brief yet informative list

• Astex. Announced 2005. For discovery, development and commercialisation of novel small molecule inhibitors of Protein Kinase B for use as anti-cancer agents. Press release
• Avanir. Announced 2005. For research and licensing in the area of Reverse Cholesterol Transport (RCT) enhancing compounds for the treatment of cardiovascular disease. Press release
• Cambridge Antibody Technology. Announced 2004. For monoclonal antibody research, in the area of inflammatory disorders, including respiratory diseases. Press release.
• Schering AG. Announced 2005. For research and licensing in the area of Selective Glucocorticoid Receptor Agonists (SEGRAs). Press release.

Astex Therapeutics is a pharmacuetical company focused on the development of treatments for medical specialty of oncology. ... Akt, also known as protein kinase B (PKB) is an important molecule in mammalian cellular signaling. ... Chemotherapy is the use of chemical substances to treat disease. ... ... Monoclonal antibodies (mAb) are antibodies that are identical because they were produced by one type of immune cell, all clones of a single parent cell. ... Inflammation is the first response of the immune system to infection or irritation and may be referred to as the innate cascade. ... In medicine, pulmonology is the specialty that deals with diseases of the lungs and the respiratory tract. ... Schering-Plough Corporation is a pharmaceutical company started in Germany by Ernst Schering in 1851. ...

See also

• List of pharmaceutical companies

This is a list of pharmaceutical and biotech companies that are major manufacturers on global or national markets : This list is incomplete; you can help by . ...

References and notes

1. ^  standard practice is that the name be pronounced as "Astra Zeneca" rather than "Astrazeneca".
2. ^  AstraZeneca - History, merger of Astra AB and Zeneca Group PLC, part of the AstraZeneca home site. Retrieved 2005-03-20. (merger and post-merger history)
3. ^  AstraZeneca: Merger partners in brief, part of the AstraZeneca home site. Retrieved 2005-03-20. (history of Astra AB and Zeneca Group PLC)
4. ^  AstraZeneca PLC (July 28, 2005). The Board of AstraZeneca PLC announces the appointment of David R Brennan as Chief Executive with effect from 1 January 2006 upon the retirement at that time of Sir Tom McKillop. Press release.
5. ^  AstraZeneca Profile. Verified availability August 5, 2005.
6. ^  Gladwell, Malcolm (October 25, 2004). "High Prices: How to think about prescription drugs". The New Yorker. Verified availability August 5, 2005.