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Encyclopedia > Atrial natriuretic peptide

Atrial natriuretic factor (ANF), atrial natriuretic peptide (ANP) or atriopeptin, is a polypeptide hormone involved in the homeostatic control of body water and sodium. It is released by atrial myocytes, cells in the atria of the heart, in response to signals of raised blood pressure and acts to reduce this. Peptides are the family of molecules formed from the linking, in a defined order, of various amino acids. ... A hormone (from Greek horman - to set in motion) is a chemical messenger from one cell (or group of cells) to another. ... Homeostasis is the property of an open system, especially living organisms, to regulate its internal environment to maintain a stable, constant condition, by means of multiple dynamic equilibrium adjustments, controlled by interrelated regulation mechanisms. ... A girl in a swimming pool Water (from the Old English waeter; c. ... General Name, Symbol, Number sodium, Na, 11 Chemical series alkali metals Group, Period, Block 1, 3, s Appearance silvery white Atomic mass 22. ... In anatomy, the atrium (plural: atria) is the blood collection chamber of a heart. ...

Contents


Structure

ANP is a 28 amino acid peptide with a 17 AA ring, and is closely related to BNP (Brain Natriuretic Peptide, but produced largely in the heart) and CNP (C-type Natriuretic Peptide) which all share the same amino acid ring. ANP was discovered in 1981 by a team in Ottawa led by Mercedes Kuroski de Bold after they made the seminal observation that injection of atrial (but not ventricular) tissue extracts into rats caused copious natriuresis. BNP can refer to British National Party Brain natriuretic peptide Backus-Naur form, a notation to describe formal languages. ... The heart and lungs, from an older edition of Grays Anatomy. ... 1981 (MCMLXXXI) was a common year starting on Thursday of the Gregorian calendar. ...


Production

ANP is produced, stored and released by cells present in the atria of the heart, atrial myocytes. It is released in response to a variety of signals, the signals mostly being present when the subject is hypervolaemic.


It is secreted in response to:

Causes of stretching include high extracellular fluid volume, high blood volume, and atrial fibrillation. Notably, it is secreted in response to immersion of the body in water, which causes an atrial stretch due to altered distribution of intravascular fluid. It has been shown that in horses, it is also released in response to exercise. The word sympathetic means different things in different contexts. ... General Name, Symbol, Number sodium, Na, 11 Chemical series alkali metals Group, Period, Block 1, 3, s Appearance silvery white Atomic mass 22. ... Angiotensinogen, angiotensin I (CAS# 9041-90-1) and angiotensin II (CAS# 11128-99-7) are peptides involved in maintenance of blood volume and pressure. ... Endothelin is a 21-amino acid vasoconstricting peptide that plays a key part in vascular homeostasis. ... A vasodilator is a substance that causes blood vessels in the body to become wider by relaxing the smooth muscle in the vessel wall, or vasodilation. ... Atrial fibrillation (AF or afib) is an abnormal heart rhythm (cardiac arrhythmia) which involves the two small, upper heart chambers (the atria). ... Binomial name Equus caballus Linnaeus, 1758 nugget For other uses, see Horse (disambiguation). ...


Receptors

There are three distinct receptors identified so far in mammals, natriuretic peptide receptors A, B and C (NPRA, NPRB and NPRC).


NPRA and NPRB are linked to guanylyl cyclases, while NPRAC is G-protein linked and furthermore is a "clearance receptor" which acts to internalise and destroy the ligand. Guanylate cyclase (EC 4. ... In cell biology, G-protein-coupled receptors, also known as GPCR, seven transmembrane receptors, heptahelical receptors, or 7TM receptors, are a class of transmembrane receptors. ...


Physiological effects

The overall effects of ANP release are a reduction in blood volume and therefore central venous pressure, cardiac output, and arterial blood pressure. It also increases renal sodium secretion and excretion.


The overall effect of which is to counter the blood pressure-raising effects of the renin-angiotensin system. Schematic depicting how the RAAS works. ...


Renal

  • Dilates the afferent glomerular arteriole, constricts the efferent glomerular arteriole, and relaxes the mesangial cells. This increases the glomerular filtration rate, resulting in greater excretion of sodium and water.
  • Inhibits renin secretion.

Mesangial cells are specialized cells around blood vessels in the kidneys. ... Glomerular filtration rate (GFR) is the volume of fluid filtered from the renal glomerular capillaries into Bowmans capsule per unit time. ... Kidney nephron The distal convoluted tubule (DCT) is a portion of kidney nephron between the loop of Henle and the collecting duct system. ... The collecting duct system of the kidney consists of a series of tubules and ducts that connect the nephrons to the ureter. ... Renin, also known as angiotensinogenase, is a circulating enzyme (EC 3. ...

Vascular

  • Relaxes vascular smooth muscle in arterioles and venules by:
    • Receptor-mediated elevation of vascular smooth muscle cGMP
    • Inhibition of the effects of catecholamines

Cyclic guanosine monophosphate (cGMP) is a second messenger derived from GTP. Cyclic guanosine monophosphate (cGMP) is a cyclic nucleotide derived from guanosine triphosphate (GTP). ...

Adrenal

Aldosterone is a steroid hormone synthesized from cholesterol by the enzyme aldosterone synthase. ... In mammals, the adrenal glands are the triangle-shaped endocrine glands that sit atop the kidneys. ...

Degradation

Degradation of ANP is needed for its actions to be stopped. It is broken down by an enzyme, neutral endopeptidase (NEP). Recently inhibitors of NEP have been developed, although have not yet been licenced, proving to be beneficial in congestive heart disease.


Other natriuretic factors

In addition to the mammalian natriuretic factors (ANP, BNP, CNP), two other peptides have been isolated. Tervonen (1998) described a salmon natriuretic factor (Salmon cardiac peptide) with a similar structure and properties and Dendroaspis Natriuretic Peptide (DNP) was discovered in the venom of the green mamba by Schweitz et al. (1992). The Chinook or King Salmon is the largest salmon in North America and can grow up to 58 long and 125 pounds. ... Mambas (family: Elapidae, genus: Dendroaspis) are tree dwelling, extremely rapidly moving snakes of Africa (Dendroaspis is literally tree snake). They are highly venomous, their venom containing neurotoxins, which can be fatal to humans without access to proper first aid and subsequent antivenom treatment. ... Species - Eastern green mamba - Jamesons mamba - Black mamba - Western green mamba Mambas, of the genus Dendroaspis, are tree dwelling extremely rapidly moving snakes of Africa. ...


References

De Bold AJ 1985 Atrial natriuretic factor: a hormone produced by the heart. Science 230:767–770.


Joshi Venugopal, Pharmacological Modulation of the Natriuretic Peptide System, Expert Opinion in Therapuetic Patents, 2003, Vol. 13, No. 9, Pages 1389-1409.[1]


Clemo HF, Baumgarten CM, Stambler BS, Wood MA, Ellenbogen KA. Atrial natriuretic factor: implications for cardiac pacing and electrophysiology. PACE Pacing Clin Electrophysiol. 1994;17:70-91.


Tervonen et al., 1998 Endocrinology 139:4021-4025.


Kokkonen et al., 2000 Am J Physiol 278: E285-E292.

Hormones and endocrine glands -

Hypothalamus: GnRH - TRH - CRH - GHRH - somatostatin - dopamine | Posterior pituitary: vasopressin - oxytocin | Anterior pituitary: GH - ACTH - TSH - LH - FSH - prolactin - MSH - endorphins - lipotropin A hormone (from Greek horman - to set in motion) is a chemical messenger from one cell (or group of cells) to another. ... An endocrine gland is one of a set of internal organs involved in the secretion of hormones into the blood. ... In the anatomy of mammals, the hypothalamus is a region of the brain located below the thalamus, forming the major portion of the ventral region of the diencephalon and functioning to regulate certain metabolic processes and other autonomic activities. ... Gonadotropin-releasing hormone 1 (GNRH1 also called LHRH) is a peptide hormone responsible for the release of FSH and LH from the anterior pituitary. ... Thyrotropin-releasing hormone (TRH) is a tripeptide hormone that stimulates the release of TSH and prolactin by the anterior pituitary. ... Corticotropin-releasing hormone (CRH), also called corticotropin-releasing factor (CRF) or corticoliberin, is a polypeptide hormone involved in the stress response. ... Growth hormone-releasing hormone (GHRH), also known as growth hormone-releasing factor (GRF or GHRF), is a 44-amino acid peptide hormone produced in the arcuate nucleus of the hypothalamus. ... Somatostatin is a hormone. ... Dopamine is a chemical naturally produced in the body. ... The posterior pituitary (also called the neurohypophysis) comprises the posterior lobe of the pituitary gland and is part of the endocrine system. ... Arginine vasopressin (AVP), also known as argipressin or antidiuretic hormone (ADH), is a human hormone that is mainly released when the body is low on water; it causes the kidneys to conserve water by concentrating the urine and reducing urine volume. ... Oxytocin is a hormone, found in mammals, which in humans is released mainly after stimulation of the nipples or distention of the vagina and which facilitates birth and breastfeeding. ... The anterior pituitary (also called the adenohypophysis) comprises the anterior lobe of the pituitary gland and is part of the endocrine system. ... Growth hormone Growth hormone is a polypeptide hormone synthesised and secreted by the anterior pituitary gland which stimulates growth and cell reproduction in humans and other vertebrate animals. ... Adrenocorticotropic hormone (ACTH or corticotropin) is a polypeptide hormone synthesised (from POMC, pre-opiomelanocortin) and secreted from corticotropes in the anterior lobe of the pituitary gland in response to the hormone corticotropin-releasing hormone (CRH) released by the hypothalamus. ... Thyroid-stimulating hormone (also known as TSH or thyrotropin) is a hormone synthesised and secreted by thyrotrope cells in the anterior pituitary gland which regulates the endocrine function of the thyroid gland. ... Luteinizing hormone (LH) is a hormone synthesised and secreted by gonadotropes in the anterior lobe of the pituitary gland. ... Follicle stimulating hormone Follicle stimulating hormone (FSH) is a hormone synthesised and secreted by gonadotropes in the anterior pituitary gland. ... Prolactin is a peptide hormone synthesised and secreted by lactotrope cells in the adenohypophysis (anterior pituitary gland). ... Melanocyte-stimulating hormone (MSH) is a peptide hormone produced by cells in the intermediate lobe of the pituitary gland. ... Endorphins are endogenous opioid biochemical compounds. ...


Thyroid: T3 and T4 - calcitonin | Parathyroid: PTH | Adrenal medulla: epinephrine - norepinephrine | Adrenal cortex: aldosterone - cortisol - DHEA | Pancreas: insulin - glucagon - somatostatin | Ovary: estradiol - progesterone - inhibin - activin | Testis: testosterone - AMH - inhibin | Pineal gland: melatonin | Kidney: renin - EPO - calcitriol - prostaglandin | Heart atrium: ANP The thyroid hormones, thyroxine (T4) and triiodothyronine (T3), are tyrosine-based hormones produced by the thyroid gland. ... Calcitonin is a a 32 amino acid polypeptide hormone that is produced in humans primarily by the C cells of the thyroid, and in many other animals in the ultimobranchial body. ... Categories: Anatomy stubs | Endocrine system ... Parathyroid hormone (PTH) is secreted by the parathyroid glands as a polypeptide containing 84 amino acids. ... Grays Fig. ... For the Deftones album; see Adrenaline (album). ... Norepinephrine or noradrenaline is a catecholamine and a phenethylamine with chemical formula C8H11NO3. ... Grays Fig. ... Aldosterone is a steroid hormone synthesized from cholesterol by the enzyme aldosterone synthase. ... Cortisol is a corticosteroid hormone that is involved in the response to stress; it increases blood pressure and blood sugar levels and suppresses the immune system. ... It has been suggested that this article or section be merged with Prasterone. ... The pancreas is an organ that serves two functions: exocrine - it produces pancreatic juice containing digestive enzymes. ... The structure of insulin. ... Glucagon ball and stick model Glucagon is a 29-amino acid polypeptide acting as an important hormone in carbohydrate metabolism. ... Somatostatin is a hormone. ... Human female internal reproductive anatomy Ovaries are egg-producing reproductive organs found in female organisms. ... Estradiol (17-beta estradiol) (also oestradiol) is a sex hormone. ... Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy (supports gestation) and embryogenesis of humans and other species. ... Inhibin is a peptide that is an inhibitor of FSH synthesis and secretion and participates in the regulation of the menstrual cycle. ... Activin is a peptide that enhances FSH synthesis and secretion and participates in the regulation of the menstrual cycle. ... Human male anatomy The testicles, known medically as testes (singular testis), are the male generative glands in animals. ... Testosterone is a steroid hormone from the androgen group. ... Anti-Müllerian hormone (AMH) is a dimeric glycoprotein that inhibits the development of the Müllerian ducts in a male embryo. ... Inhibin is a peptide that is an inhibitor of FSH synthesis and secretion and participates in the regulation of the menstrual cycle. ... Diagram of pituitary and pineal glands. ... Structuring urgently requested // Definition Melatonin, 5-methoxy-N-acetyltryptamine, is a hormone found in all living creatures that have been studied from algae [1] to humans, at levels that vary in a diurnal cycle. ... Human kidneys viewed from behind with spine removed The kidneys are bean-shaped excretory organs in vertebrates. ... Renin, also known as angiotensinogenase, is a circulating enzyme (EC 3. ... Erythropoietin Erythropoietin (or EPO) is a glycoprotein hormone that is a growth factor for erythrocyte (red blood cell) precursors in the bone marrow. ... Vitamin D is a fat soluble vitamin that contributes to the maintenance of normal levels of calcium and phosphorus in the bloodstream. ... Chemical structure of prostaglandin E1 (PGE1). ... In anatomy, the atrium (plural: atria) is the blood collection chamber of a heart. ...


Stomach: gastrin | Duodenum: CCK - GIP - secretin - motilin - VIP | Ileum: enteroglucagon | Liver: IGF-1 In anatomy, the stomach (in ancient Greek στόμαχος) is an organ in the gastrointestinal tract used to digest food. ... In humans, gastrin is a hormone that stimulates secretion of gastric acid by the stomach. ... In anatomy of the digestive system, the duodenum is a hollow jointed tube connecting the stomach to the jejunum. ... Cholecystokinin (from Greek chole, bile; cysto, sac; kinin, move; hence, move the bile-sac (gall bladder)) is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and protein. ... Gastric inhibitory peptide (GIP) is a gastrointestinal hormone secreted by the duodenum. ... Secretin is a peptide hormone produced in the S cells of the duodenum. ... Motilin is a polypeptide hormone secreted by the small intestine that increases gastrointestinal motility and stimulates the production of pepsin. ... VIP is a peptide hormone containing 28 amino acid residues. ... Grays Fig. ... An editor has expressed a concern that the topic of this article may be unencyclopedic. ... The liver is the largest internal organ in the human body. ... The insulin-like growth factors (IGFs) are polypeptides with high sequence similarity to insulin. ...


Placenta: hCG - HPL - estrogen - progesterone The placenta is an ephemeral (temporary) organ present only in female placental mammals during gestation (pregnancy). ... Human chorionic gonadotropin (hCG) is a peptide hormone produced in pregnancy, that is made by the embryo soon after conception and later by the trophoblast (part of the placenta). ... Human placental lactogen (HPL), also called human chorionic somatomammotropin, is a polypeptide placental hormone. ... Estrogens (also oestrogens) are a group of steroid compounds, named for their importance in the oestrus cycle, functioning as the primary female sex hormone. ... Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy (supports gestation) and embryogenesis of humans and other species. ...


Adipose tissue: leptin Adipose tissue is an anatomical term for loose connective tissue composed of adipocytes. ... Leptin is a 16 kDa protein hormone that plays a key role in regulating energy intake and energy expenditure (appetite and metabolism). ...

Urinary system - Kidney - edit
Renal capsule | Renal cortex | Renal medulla (Renal sinusRenal pyramids) | Renal calyx | Renal pelvis
Nephron - Renal corpuscle (GlomerulusBowman's capsule) → Proximal tubule → Loop of Henle → Distal convoluted tubule → Collecting ducts

Juxtaglomerular apparatus (Macula densaJuxtaglomerular cells) The urinary system is the organ system that produces, stores, and carries urine. ... Human kidneys viewed from behind with spine removed The kidneys are bean-shaped excretory organs in vertebrates. ... The renal capsule is a tough fibrous layer surrounding the kidney and covered in a thick layer of perinephric adipose tissue. ... The renal cortex is the outer portion of the kidney between the renal capsule and the renal medulla. ... The renal medulla is the innermost part of the kidney. ... The renal sinus is a cavity within the kidney which is occupied by the renal pelvis, renal calices, blood vessels, nerves and fat. ... Renal pyramids are cone-shaped tissues of the kidney. ... A calyx is a part in the kidney. ... The renal pelvis represents the dilated proximal part of the ureter. ... Nephron of the kidney A nephron is the basic structural and functional unit of the kidney. ... A renal corpuscle is the initial filtering component of a nephron in the kidney. ... Glomerulus refers to two unrelated structures in the body, both named for their globular form. ... Bowmans capsule is a blind sac at the beginning of the tubular component of a nephron in the mammalian kidney. ... The loop of Henle is a section of the nephron that leads from the proximal convoluted tubule to the distal convoluted tubule in the kidney. ... Kidney nephron The distal convoluted tubule (DCT) is a portion of kidney nephron between the loop of Henle and the collecting duct system. ... The collecting duct system of the kidney consists of: The connecting tubule The cortical collecting duct The medullary collecting duct Categories: | ... The juxtaglomerular apparatus is a renal structure consisting of the macula densa and juxtaglomerular cells. ... In the kidney, the macula densa is an area of closely packed specialized cells lining the distal convoluted tubule where it lies next to the glomerular vascular pole. ... The juxtaglomerular cells are specialized cells that stimulate the secretion of the adrenal hormone aldosterone and play a major role in renal autoregulation, the kidneys self-governance. ...


Renal circulation - Renal artery → Interlobar arteries → Arcuate arteries → Cortical radial arteries → Afferent arterioles → Glomerulus → Efferent arterioles → Vasa recta → Arcuate vein → Renal vein Grays Fig. ... Human kidneys viewed from behind with spine removed The renal arteries normally arise off the abdominal aorta and supply the kidneys with blood. ... The afferent arterioles are a group of blood vessels that supply the nephrons in many excretory systems. ... The glomerulus is a capillary bed found surrounded by the Bowmans capsule of the nephron in the vertebrate kidney. ... The Efferent arterioles are a group of blood vessels that are part of the urinary system of many animals. ... A nephron, the vasa recta is labelled arteria recta The vasa recta is a loop of the renal circulation that surrounds the Loop of Henle, part of the nephron in the medulla of the kidney. ... Kidneys viewed from behind with spine removed The kidneys are bean-shaped excretory organs in vertebrates. ...

Renal physiology
Filtration - Ultrafiltration | Countercurrent exchange

Hormones effecting filtration - Antidiuretic hormone (ADH) | Aldosterone | Atrial natriuretic peptide Renal physiology is the study of the physiology of the kidneys. ... In chemistry and alchemy, filtration is the process of using a filter to mechanically separate a mixture. ... Ultrafiltration (UF) is a pressure-driven membrane process for purifying and concentrating macromolecular (10^3 - 10^6 Da) solutions, especially protein solutions. ... Countercurrent exchange is a mechanism used to transfer some component of a fluid from one flowing current of fluid to another across a permeable barrier between them. ... Antidiuretic hormone (ADH), or arginine vasopressin (AVP), is a peptide hormone produced by the hypothalamus, and stored in the posterior part of the pituitary gland. ... Aldosterone is a steroid hormone synthesized from cholesterol by the enzyme aldosterone synthase. ...


Endocrine - Renin | Erythropoietin (EPO) | Calcitriol (Active vitamin D) | Prostaglandins The endocrine system is a control system of ductless endocrine glands that secrete chemical messengers called hormones that circulate within the body via the bloodstream to affect distant organs. ... Renin, also known as angiotensinogenase, is a circulating enzyme (EC 3. ... Erythropoietin Erythropoietin (or EPO) is a glycoprotein hormone that is a growth factor for erythrocyte (red blood cell) precursors in the bone marrow. ... Vitamin D is a fat soluble vitamin that contributes to the maintenance of normal levels of calcium and phosphorus in the bloodstream. ... Chemical structure of prostaglandin E1 (PGE1). ...

Assessing Renal function / Measures of Dialysis
Glomerular filtration rate | Creatinine clearance | Renal clearance ratio | Urea reduction ratio | Kt/V | Standardized Kt/V | Hemodialysis product

  Results from FactBites:
 
Rollin, Mol Vis 2004; 10:450-457. (4860 words)
ANP was detected in the fibrovascular epiretinal tissue of patients with PDR.
ANP is a member of the natriuretic peptide (NP) family, a group of cardiovascular cyclic peptide hormones with diuretic, natriuretic, and vasodilatory properties [12].
Given that ANP is an antiangiogenic [11] and vascular antipermeability factor [25], we suggest that this peptide may have a role in the vascular pathobiology of diabetic retinopathy.
Atrial natriuretic peptide - Wikipedia, the free encyclopedia (853 words)
Atrial natriuretic factor (ANF), atrial natriuretic peptide (ANP) or atriopeptin, is a polypeptide hormone involved in the homeostatic control of body water,sodium, and adiposity.
ANP is a 28 amino acid peptide with a 17 AA ring, and is closely related to BNP (Brain Natriuretic Peptide, but produced largely in the heart) and CNP (C-type Natriuretic Peptide) which all share the same amino acid ring.
ANP was discovered in 1981 by a team in Ottawa led by Mercedes Kuroski de Bold after they made the seminal observation that injection of atrial (but not ventricular) tissue extracts into rats caused copious natriuresis.
  More results at FactBites »


 
 

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