The Auglaize River is a tributary of the Maumee River, approximately 100 mi (161 km) long, in northwestern Ohio in the United States. It drains a primarily rural farming area in the watershed of Lake Erie. The name of the river comes from a Shawnee phrase meaning "fallen timbers".
It rises in southeastern Allen County, approximately 10 mi (16 km) southeast of Lima and 12 mi (19 km) north of Indian Lake. It flows southwest to Wapakoneta, then generally north in a zigzag course, past Delphos, Fort Jennings and Oakwood. It joins the Maumee from the south at Defiance, approximately 2 mi (3.2 km) east of the mouth of the Tiffin River.
During the days of the Ohio Country in the 18th century, the area around the river was inhabited by the Ottawa. Fort Amanda, constructed along the river southwest of Lima in 1812, was an important American outpost during the War of 1812. Fort Defiance was constructed in 1812 near the confluence of the Auglaize and the Maumee where the Battle of Fallen Timbers was fought.