He was made governor of Britain in AD 52, inheriting the post from Ostorius Scapula at a time when the situation was deteriorating as a result of a string of rebellions.
Didius acted to quell the rebels rather than enlarge the empire during his rule which lasted until AD 57. Although criticised by Tacitus as being reactive and defensive, he was probably acting on instructions from Claudius who did not consider the benefits of further conquest in difficult terrain to be great enough to warrant the risk. Instead, Didius built roads and forts at the borders such as those at Usk to contain the barbarians.
Venutius' first insurrection against Queen Cartimandua of the Brigantes occurred during Didius' rule and he despatched troops to aid her. Didius was replaced by Quintus Veranius.