A: bistability as a basis of memory effects in autocrine loops with positive feedback: steady levels of intracellular signaling activity in a model autocrine loop were computed as a function of (steady) exogenous stimulus.
Autocrine loop in the "on" state (A) converts transient external perturbation (B) to a long-lasting and dynamic transient of the intracellular signaling (C).
Autocrine loop is interrupted when the cell has a low number of surface receptors (D) or when the endogenous ligands are captured by components of the cellular microenvironment (E).
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