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Encyclopedia > Avian Flu
Flu

Avian influenza (also bird flu) is the collective term for influenza from viruses adapted to birds. Sometimes the term is mistakenly used to refer to specific Influenza A subtypes, or to the specific viruses that cause the disease (see Virus versus disease).[1][2][3][4][5][6][7] Image File history File links Broom_icon. ... Image File history File links Broom_icon. ... Influenza A virus subtype H5N1, also known as A(H5N1) or simply H5N1, is a subtype of the Influenza A virus which can cause illness in humans and many other animal species. ... The global spread of H5N1 in birds is considered a significant pandemic threat. ... See Epidemiology of WHO-confirmed human cases of avian influenza A(H5N1) infection. ... Image File history File links Flu_und_legende_color_c. ... Influenza, commonly known as flu, is an infectious disease of birds and mammals caused by an RNA virus of the family Orthomyxoviridae (the influenza viruses). ... Genera Influenzavirus A Influenzavirus B Influenzavirus C Isavirus Thogotovirus The Orthomyxoviridae are a family of RNA viruses which infect vertebrates. ... Avian influenza (also known as bird flu, avian flu, influenzavirus A flu, type A flu, or genus A flu) is a flu (influenza) due to a type of influenza virus that is hosted by birds, but may infect several species of mammals. ... Flu season is mostly a colloquial term used to describe the regular outbreak in flu cases, or even cases of the common cold during the late fall or winter. ... Flu research includes molecular virology, pathogenesis, host immune responses, genomics, and epidemiology. ... Model of Influenza Virus from NIH The flu vaccine is a vaccine to protect against the highly variable influenza virus. ... This article is about flu treatment in humans for mild human flu, which includes both efforts to reduce symptoms and to battle the flu virus itself. ... The Influenza Genome Sequencing Project is funded by the National Institute of Allergy and Infectious Diseases (NIAID) which is a component of the National Institutes of Health (NIH), which is an agency of the United States Department of Health and Human Services. ... Influenza A virus subtype H5N1, also known as A(H5N1) or simply H5N1, is a subtype of the Influenza A virus which can cause illness in humans and many other animal species. ... Influenza, commonly known as flu, is an infectious disease of birds and mammals caused by an RNA virus of the family Orthomyxoviridae (the influenza viruses). ... This article is about biological infectious particles. ... For other uses, see Bird (disambiguation). ... Genera Influenzavirus A Influenzavirus B Influenzavirus C Isavirus Thogotovirus Influenzavirus A is a genus of a family of viruses called Orthomyxoviridae in virus classification. ... Genera Influenzavirus A Influenzavirus B Influenzavirus C Isavirus Thogotovirus The Orthomyxoviridae are a family of RNA viruses which infect vertebrates. ...

Contents

Virus

"Bird flu" is one of many different types of influenza that are typically named after the preferred host organism for the virus, other similarily named influenzas are "Swine flu", "Dog flu", "Horse flu", and "Human flu". Avian influenza differs slightly as it is named after an an entire vertebrate class with 8,800–10,200 species. All known viruses that cause avian influenza belong to the species of virus called Influenzavirus A[citation needed]. Influenzavirus A are predominantly adapted to birds[citation needed], which is why for many purposes avian flu virus is the Influenza A virus[citation needed] (note that the "A" does not stand for "avian"[citation needed]). Swine Flu is a form of Type A influenza that is normally virulent only in pigs. ... Canine influenza or dog flu refers to varieties of influenzavirus A that affect dogs. ... Horse flu (or Equine influenza) refers to varieties of influenzavirus A that are endemic in horses. ... Human Flu refers to a subset of Orthomyxoviridae that create influenza in humans and are endemic in humans. ... For other meanings of bird, see bird (disambiguation). ... Genera Influenzavirus A Influenzavirus B Influenzavirus C Isavirus Thogotovirus Influenzavirus A is a genus of the family of viruses called Orthomyxoviridae in virus classification. ...


Adaptation is sometimes partial or multiple so a flu virus strain can be partially adapted to a species or adapted to more than one species[citation needed]. Influenza pandemic viruses are human adapted and also bird adapted. Being adapted to one species does not mean another species can not catch it; nor does it mean it can not adapt to another species. An influenza pandemic is a large scale epidemic of the influenza virus, such as the 1918 Spanish flu. ...


Genetics

Genetic factors in distinguishing between "human flu viruses" and "avian flu viruses" include:

PB2: (RNA polymerase): Amino acid (or residue) position 627 in the PB2 protein encoded by the PB2 RNA gene. Until H5N1, all known avian influenza viruses had a Glu at position 627, while all human influenza viruses had a lysine.
HA: (hemagglutinin): Avian influenza HA bind alpha 2-3 sialic acid receptors while human influenza HA bind alpha 2-6 sialic acid receptors. Swine influenza viruses have the ability to bind both types of sialic acid receptors.

This article does not cite any references or sources. ... Phenylalanine is one of the standard amino acids. ... A residue, broadly, is anything left behind by a reaction or event. ... Ribonucleic acid or RNA is a nucleic acid polymer consisting of nucleotide monomers that plays several important roles in the processes that translate genetic information from deoxyribonucleic acid (DNA) into protein products; RNA acts as a messenger between DNA and the protein synthesis complexes known as ribosomes, forms vital portions... Influenza A virus subtype H5N1, also known as A(H5N1) or simply H5N1, is a subtype of the Influenza A virus which can cause illness in humans and many other animal species. ... Glutamic acid (Glu, E), is the protonated form of glutamate (the anion). ... Lysine is one of the 20 amino acids normally found in proteins. ... Hemagglutinin, as depicted in a simplified molecular model. ... Sialic acid is a generic term for the N- or O-substituted derivatives of neuraminic acid, a nine-carbon monosaccharide. ... Swine Flu refers to a subset of Orthomyxoviridae that create influenza in pigs and are endemic in pigs. ...

Symptoms

Once diagnosed, the symptoms of bird flu include, coughing, running nose, drowsiness, along with many others. If not cured rapidly, the symptoms can get worse, possibly resulting in paralysis, and sometimes death.


Influenza pandemic

For more details on this topic, see Influenza pandemic.

Pandemic flu viruses have some avian flu virus genes and usually some human flu virus genes. Both the H2N2 and H3N2 pandemic strains contained genes from avian influenza viruses. The new subtypes arose in pigs coinfected with avian and human viruses and were soon transferred to humans. Swine were considered the original "intermediate host" for influenza, because they supported reassortment of divergent subtypes. However, other hosts appear capable of similar coinfection (e.g., many poultry species), and direct transmission of avian viruses to humans is possible. The Spanish flu virus strain may have been transmitted directly from birds to humans.[8] An influenza pandemic is a large scale epidemic of the influenza virus, such as the 1918 Spanish flu. ... Human Flu refers to a subset of Orthomyxoviridae that create influenza in humans and are endemic in humans. ... The Asian Flu was a pandemic outbreak of influenza that originated in China in 1957 and spread worldwide that same year. ... H3N2 is a subtype of the species Influenza A virus (sometimes called bird flu virus). ...


In spite of their pandemic connection, avian influenza viruses are noninfectious for most species. When they are infectious they are usually asymptomatic, so the carrier does not have any disease from it. Thus while infected with an avian flu virus, the animal doesn't have a "flu". Typically, when illness (called "flu") from an avian flu virus does occur, it is the result of an avian flu virus strain adapted to one species spreading to another species (usually from one bird species to another bird species). So far as is known, the most common result of this is an illness so minor as to be not worth noticing (and thus little studied). But with the domestication of chickens and turkeys, humans have created species subtypes (domesticated poultry) that can catch an avian flu virus adapted to waterfowl and have it rapidly mutate into a form that kills in days over 90% of an entire flock and spread to other flocks and kill 90% of them and can only be stopped by killing every domestic bird in the area. Until H5N1 infected humans in the 1990s, this was the only reason avian flu was considered important. Since then, avian flu viruses have been intensively studied; resulting in changes in what is believed about flu pandemics, changes in poultry farming, changes in flu vaccination research, and changes in flu pandemic planning. Respiratory disease properly named influenza(say: in-floo-en-zah ). Some specific varities of influenza with a vaccination available are: A-New Caledonia, A-California, B-Shanghai. ... For other uses, see Bird (disambiguation). ... Influenza A virus subtype H5N1, also known as A(H5N1) or simply H5N1, is a subtype of the Influenza A virus which can cause illness in humans and many other animal species. ...


H5N1 has evolved into a flu virus strain that infects more species than any previously known flu virus strain, is deadlier than any previously known flu virus strain, and continues to evolve becoming both more widespread and more deadly causing a leading expert on avian flu to publish an article titled "The world is teetering on the edge of a pandemic that could kill a large fraction of the human population" in American Scientist. He called for adequate resources to fight what he sees as a major world threat to possibly billions of lives.[9] Since the article was written, the world community has spent billions of dollars fighting this threat with limited success[citation needed]. Influenza A virus subtype H5N1, also known as A(H5N1) or simply H5N1, is a subtype of the Influenza A virus which can cause illness in humans and many other animal species. ... Robert G. (Rob) Webster (born May 7, 1932), in Balclutha New Zealand, is the virologist who in 1957 was the first to announce a link between human flu and bird flu. ... American Scientist (ISSN 0003-0996) is an illustrated bimonthly magazine about science and technology. ...


H5N1

For more details on this topic, see H5N1 and H5N1 flu.
Cumulate Human Cases of and Deaths from H5N1
As of April 11, 2007
Image:H5n1 spread (with regression).png

Notes: Influenza A virus subtype H5N1, also known as A(H5N1) or simply H5N1, is a subtype of the Influenza A virus which can cause illness in humans and many other animal species. ... The transmission and infection of H5N1 is a concern due to the global spread of H5N1 that constitutes a pandemic threat. ... Influenza A virus subtype H5N1, also known as A(H5N1) or simply H5N1, is a subtype of the Influenza A virus which can cause illness in humans and many other animal species. ... is the 101st day of the year (102nd in leap years) in the Gregorian calendar. ... Year 2007 (MMVII) is the current year, a common year starting on Monday of the Gregorian calendar and the AD/CE era. ... Image File history File links H5n1_spread_(with_regression). ...

As of 2007, "avian flu" is being commonly used[citation needed] to refer to infection from a particular subtype of Influenza A virus, H5N1, which can cause severe illness in humans who are infected. This strain is transmitted through contact with infected birds, but has only been transmitted from one person to another in a few cases. H5N1 flu is therefore not at pandemic now and is not currently capable of causing a pandemic[citation needed]. Only if H5N1 mutates into a form that can be readily transmitted from one person to another could it cause a pandemic[citation needed]. The World Health Organization (WHO) is a specialized agency of the United Nations (UN) that acts as a coordinating authority on international public health. ... Generally, regression is related to moving backwards, and the opposite of progression. ... Year 2007 (MMVII) is the current year, a common year starting on Monday of the Gregorian calendar and the AD/CE era. ... Influenza A virus subtype H5N1, also known as A(H5N1) or simply H5N1, is a subtype of the Influenza A virus which can cause illness in humans and many other animal species. ...


On August 22, 2007, an Indonesian woman, 28, chicken trader was the 2nd person to die of bird flu on Bali, raising the death toll in the nation due to the disease to 84 (after 4 days of hospitalization). Tests in 2 local laboratories was positive for the H5N1 strain of the disease. 194 people — the majority of them in Indonesia died since 2003, according to the World Health Organization. [10] is the 234th day of the year (235th in leap years) in the Gregorian calendar. ... Year 2007 (MMVII) is the current year, a common year starting on Monday of the Gregorian calendar and the AD/CE era. ... Avian influenza (also known as bird flu) is a type of influenza virulent in birds. ... This article is about the Indonesian island. ... Influenza A virus subtype H5N1, also known as A(H5N1) or simply H5N1, is a subtype of the Influenza A virus which can cause illness in humans and many other animal species. ... The World Health Organization (WHO) is a specialized agency of the United Nations (UN) that acts as a coordinating authority on international public health. ...


See also

Subtypes of bird flu

Genera Influenzavirus A Influenzavirus B Influenzavirus C Isavirus Thogotovirus Influenzavirus A is a genus of the family of viruses called Orthomyxoviridae in virus classification. ... An influenza pandemic is a large scale epidemic of the influenza virus, such as the 1918 Spanish flu. ... The Influenza Genome Sequencing Project is funded by the National Institute of Allergy and Infectious Diseases (NIAID) which is a component of the National Institutes of Health (NIH), which is an agency of the United States Department of Health and Human Services. ... Model of Influenza Virus from NIH The flu vaccine is a vaccine to protect against the highly variable influenza virus. ... Flu research includes molecular virology, pathogenesis, host immune responses, and epidemiology. ... OFFLU is the OIE/FAO Network of Expertise on Avian Influenza. ... President George W. Bush announced the International Partnership on Avian and Pandemic Influenza in his remarks to the High-Level Plenary Meeting of the United Nations General Assembly on September 14, 2005, in New York. ... The Pandemic Preparedness and Response Act is a bill introduced on October 5, 2005 by Democratic Senators Harry Reid, Evan Bayh, Dick Durbin, Ted Kennedy, Barack Obama, and Tom Harkin in response to the growing threat of an outbreak of the Avian Flu. ... H1N1 is a subtype of the species Influenza A virus (sometimes called bird flu virus). ... H1N2 is a subtype of the species avian influenza virus (bird flu virus) currently endemic in both human and pig populations. ... The Asian Flu was a pandemic outbreak of influenza that originated in China in 1957 and spread worldwide that same year. ... H3N2 is a subtype of the species Influenza A virus (sometimes called bird flu virus). ... H3N8 is a subtype of the species avian influenza virus (bird flu virus). ... Influenza A virus subtype H5N1, also known as A(H5N1) or simply H5N1, is a subtype of the Influenza A virus which can cause illness in humans and many other animal species. ... H5N2 is a strain of avian influenza virus. ... H5N3 is a subtype of the species Influenza A virus (sometimes called bird flu virus). ... H5N8 is a subtype of the species Influenzavirus A (avian influenza virus or bird flu virus). ... H5N9 is a subtype of the species Influenzavirus A (avian influenza virus or bird flu virus). ... H5N8 is a subtype of the species Influenzavirus A (avian influenza virus or bird flu virus). ... H7N1 is a subtype of the species Influenzavirus A (avian influenza virus or bird flu virus). ... H7N2 is a subtype of the species avian influenza virus (bird flu virus). ... H7N3 is a subtype of the species avian influenza virus (bird flu virus). ... H7N4 is a subtype of the species Influenzavirus A (avian influenza virus or bird flu virus). ... H7N7 is a subtype of the species avian influenza virus (bird flu virus). ... H9N2 is a subtype of the species avian influenza virus (bird flu virus). ... H10N7 is a subtype of the species avian influenza virus (bird flu virus). ...

Sources and notes

  1. ^ "Avian influenza strains are those well adapted to birds"EUROPEAN CENTRE FOR DISEASE PREVENTION AND CONTROL.
  2. ^ Chapter Two : Avian Influenza by Timm C. Harder and Ortrud Werner in Influenza Report 2006
  3. ^ Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution Nature magazine presents a summary of what has been discovered in the Influenza Genome Sequencing Project.
  4. ^ FAvian Influenza A (H5N1) Infection in Humans by The Writing Committee of the World Health Organization (WHO) Consultation on Human Influenza A/H5 in the September 29, 2005 New England Journal of Medicine
  5. ^ The Threat of Pandemic Influenza: Are We Ready? Workshop Summary (2005) Full text of online book by INSTITUTE OF MEDICINE OF THE NATIONAL ACADEMIES
  6. ^ Here is the tree showing evolution by antigenic drift since 2002 that created dozens of highly pathogenic varieties of the Z genotype of avian flu virus H5N1, some of which are increasingly adapted to mammals.
  7. ^ Evolutionary characterization of the six internal genes of H5N1 human influenza A virus
  8. ^ Chapter Two : Avian Influenza by Timm C. Harder and Ortrud Werner
  9. ^ Webster, R. G. and Walker, E. J. (2003). "The world is teetering on the edge of a pandemic that could kill a large fraction of the human population". American Scientist 91 (2): 122. doi:10.1511/2003.2.122. 
  10. ^ ITH, Bird flu kills Balinese woman, raises death toll to 84

The Influenza Genome Sequencing Project is funded by the National Institute of Allergy and Infectious Diseases (NIAID) which is a component of the National Institutes of Health (NIH), which is an agency of the United States Department of Health and Human Services. ... The World Health Organization (WHO) is a specialized agency of the United Nations (UN) that acts as a coordinating authority on international public health. ... is the 272nd day of the year (273rd in leap years) in the Gregorian calendar. ... Year 2005 (MMV) was a common year starting on Saturday (link displays full calendar) of the Gregorian calendar. ... The New England Journal of Medicine (New Engl J Med or NEJM) is a peer-reviewed medical journal published by the Massachusetts Medical Society. ... Antigenic drift refers to mutations in the influenza virus over time. ... A pathogen (literally birth of pain from the Greek παθογένεια) is a biological agent that can cause disease to its host. ... Robert G. (Rob) Webster (born May 7, 1932), in Balclutha New Zealand, is the virologist who in 1957 was the first to announce a link between human flu and bird flu. ... A digital object identifier (or DOI) is a standard for persistently identifying a piece of intellectual property on a digital network and associating it with related data, the metadata, in a structured extensible way. ...

External links

Wikinews has related news:
Category:Avian Flu
International
World Health Organisation (WHO)
    • WHO Avian influenza resource (updated)
    • The United Nation's World Health Organization's Avian Flu Facts Sheet for 2006
Food and Agriculture Organization of the UN (FAO)
    • FAO Avian Influenza portal Information resources, animations, videos, photos
    • FAO Bird Flu disease card
World Organisation for Animal Health (OIE)
    • Official outbreak reports by country
    • Official outbreak reports by week
United States
  • PandemicFlu.Gov U.S. Government avian and pandemic flu information
  • US Avian Influenza Response U.S. Agency for International Development (USAID)
  • Key Facts About Avian Influenza (Bird Flu) and Avian Influenza A (H5N1) Virus Centers for Disease Control (CDC)
Europe
  • Avian Influenza: Prevention and Control Proceedings of the Frontis workshop on Avian Influenza: Prevention and Control, Wageningen, The Netherlands
Other
  • Flu Wiki
  • The spread of avian flu with time; new maps exploiting Google Earth’s time series function updated Google Earth maps of bird flu spread by Nature reporter Declan Butler
  • birdfluthreat.org information page

  Results from FactBites:
 
Avian flu - Wikipedia, the free encyclopedia (1879 words)
Avian flu (also "bird flu", "avian influenza", "bird influenza"), means "flu from viruses adapted to birds", but is sometimes mistakenly used to refer to both other flu subsets and the viruses that cause them.
As of 2006, "avian flu" is being commonly used to refer to infection from a particular subtype of Influenza A virus, H5N1, which can cause severe illness in humans who are infected.
Avian Influenza (Bird Flu): Agricultural and Wildlife Considerations
Avian Flu - MSN Encarta (829 words)
Avian Flu, also known as bird flu, an infectious disease of wild and domestic birds, caused by a range of viruses known as Type A influenza viruses.
Avian influenza was not known to directly infect humans until 1997, when an outbreak in Hong Kong, China, caused by infected poultry, sickened 18 people, killing 6 of them.
Although humans have a degree of immunity to the influenza subtypes that circulate during the winter flu season, the human immune system is unaccustomed to recognizing and fighting off avian influenza.
  More results at FactBites »


 
 

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