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Encyclopedia > Avram Hershko

Avram Hershko (Hebrew: אברהם הרשקו‎, born Herskó Ferenc, 31 December 1937) is an Israeli biologist. “Hebrew” redirects here. ... is the 365th day of the year (366th in leap years) in the Gregorian calendar. ... Year 1937 (MCMXXXVII) was a common year starting on Friday (link will display the full calendar) of the Gregorian calendar. ... Biology studies the variety of life (clockwise from top-left) E. coli, tree fern, gazelle, Goliath beetle Biology (from Greek: βίος, bio, life; and λόγος, logos, knowledge), also referred to as the biological sciences, is the study of living organisms utilizing the scientific method. ...


Born in Karcag, Jász-Nagykun-Szolnok county, Hungary, he received his M.D. in 1965 and his Ph. D in 1969 from the Hadassah Faculty of Medicine in the Hebrew University of Jerusalem. He is currently a Distinguished Professor at the Rappaport Family Institute for Research in Medical Sciences at the Technion in Haifa and Adjunct Professor of Pathology at New York University. Location of Jász-Nagykun-Szolnok county in Hungary Karcag is a large town in Jász-Nagykun-Szolnok county, in the Northern Great Plain region of central Hungary. ... This article is about the modern county, for the historical one see Jász-Nagykun-Szolnok (former county). ... The Hebrew University of Jerusalem (‎, Arabic: ) is one of Israels oldest, largest, and most important institutes of higher learning and research. ... Computer Science Faculty Building The Technion – Israel Institute of Technology (‎; commonly abbreviated as Technion IIT) is a university in Haifa, Israel, founded 1924. ... Hebrew חֵיפָה Arabic حَيْفَا Founded in 3rd century CE Government City District Haifa Population 267,000 1,039,000 (metropolitan area) Jurisdiction 63,666 dunams (63. ... New York University (NYU) is a private, nonsectarian, coeducational research university in New York City. ...


In 2000 he received the Albert Lasker Award for Basic Medical Research. Along with Aaron Ciechanover and Irwin Rose, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation. The ubiquitin-proteasome pathway has a critical role in maintaining the homeostasis of cells and is believed to be involved in the development and progression of diseases such as: cancer, muscular and neurological diseases, immune and inflammatory responses. Year 2000 (MM) was a leap year starting on Saturday (link will display full 2000 Gregorian calendar). ... The Albert Lasker Award for Basic Medical Research is awarded by the Lasker Foundation for the understanding, diagnosis, prevention, treatment, and cure of disease. ... Aaron Ciechanover (אהרון צחנובר) (born October 1, 1947) is an Israeli biologist. ... Irwin A. Rose (born 16 July 1926 in NY) is an American biologist. ... This is a list of Nobel Prize laureates in Chemistry from 1901 to 2006. ... Ubiquitin is a very conserved small regulatory protein that is ubiquitous in eukaryotes. ... Proteolysis is the directed degradation (digestion) of proteins by cellular enzymes called proteases or by intramolecular digestion. ...


Honors and awards

  • 1987 - Weizmann Prize for Sciences (Israel)
  • 1993 - Elected to the European Molecular Biology Organization
  • 1994 - Israel Prize in Biochemistry and Medicine
  • 1999 - Wachter Prize, by the University of Innsbruck, Austria (with A. Ciechanover)
  • 1999 - Gairdner International Award, by the Gairdner Foundation, Canada (with A. Varshavsky)
  • 2000 - Albert Lasker Award for Basic Medical Research
  • 2001 - Louisa Gross Horwitz Prize
  • 2004 - Nobel Prize in Chemistry

Louisa Gross Horwitz Prize for Biology or Biochemistry is an annual prize awarded by Columbia University to a researcher or group of researchers that have made an outstanding contribution in basic research in the fields of biology or biochemistry. ...

Publications

  • Hershko, A., Ciechanover, A., and Rose, I.A. (1979) "Resolution of the ATP-dependent proteolytic system from reticulocytes: A component that interacts with ATP". Proc. Natl. Acad. Sci. USA 76, pp. 3107-3110.
  • Hershko, A., Ciechanover, A., Heller, H., Haas, A.L., and Rose I.A. (1980) "Proposed role of ATP in protein breakdown: Conjugation of proteins with multiple chains of the polypeptide of ATP-dependent proteolysis". Proc. Natl. Acad. Sci. USA 77, pp. 1783-1786.
  • Ciechanover, A., Elias, S., Heller, H. and Hershko, A. (1982) Covalent affinity purification of ubiquitin-activating enzyme. J. Biol. Chem. 257, 2537-2542.
  • Hershko, A., Heller, H., Elias, S. and Ciechanover, A. (1983) Components of ubiquitin-protein ligase system: resolution, affinity purification and role in protein breakdown. J. Biol. Chem. 258, 8206-8214.
  • Hershko, A., Leshinsky, E., Ganoth, D. and Heller, H. (1984) ATP-dependent degradation of ubiquitin-protein conjugates. Proc. Natl. Acad. Sci. USA 81, 1619-1623.
  • Hershko, A., Heller, H., Eytan, E. and Reiss, Y. (1986) The protein substrate binding site of the ubiquitin-protein ligase system. J. Biol. Chem. 261, 11992-11999.
  • Ganoth, D., Leshinsky, E., Eytan, E., and Hershko, A. (1988) A multicomponent system that degrades proteins conjugated to ubiquitin. Resolution of components and evidence for ATP-dependent complex formation. J. Biol. Chem. 263, 12412-1241.

External links


  Results from FactBites:
 
Avram Hershko (323 words)
Avram Hershko was born in 1937, in Karcag, Hungary.
Hershko is a Distinguished Professor at the Unit of Biochemistry, the Rappaport Faculty of Medicine at the Technion (Israel Institute of Technology) in Haifa, Israel.
Hershko, A., Ciechanover, A., Heller, H., Haas, A. L., and Rose, I. (1980) Proposed role of ATP in protein breakdown: conjugation of proteins with multiple chains of the polypeptide of ATP-dependent proteolysis.
Hershko, Avram - MSN Encarta (691 words)
Hershko, Avram, born in 1937, Hungarian-born Israeli biochemist and cowinner of the 2004 Nobel Prize in chemistry for his role in discovering the process by which cells apply a molecular “tag” to certain proteins, marking them for destruction.
When Hershko and his colleagues began their research in the 1970s, many scientists had studied the process by which cells assemble the hundred thousand or so different proteins that fulfill many vital cellular functions.
Hershko and Ciechanover, who was then his graduate student, decided to study a question that had puzzled biochemists since the 1950s: why the breakdown of a cell’s own proteins require energy on the part of the cell, when other forms of protein degradation do not consume the cell’s energy.
  More results at FactBites »

 

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