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Several years later, vitamin B3 was formally identified as the missing nutrient in the cornmeal-based diets that had led to the symptoms of pellagra.
The relationship between vitamin B3 and DNA damage appears to be particularly important in relationship to cancer and its prevention.
Vitamin B3 deficiency also appears to be related to vitamin B12 status, since even mild deficiencies in vitamin B12 can increase loss of vitamin B3 in the urine.