BRCA2 refers to either a gene (BReast-CAncer susceptibility gene 2, located on human chromosome 13, 13q12-13) or the protein coded for by that gene. The BRCA2 protein functions as a tumor suppressor. Like the BRCA1 protein, BRCA2 seems to function in the cell nucleus to repair damaged DNA. Mutations in the genes that code for the BRCA1 and BRCA2 proteins can result in defective repair of damaged DNA, accumulation of mutations, and tumor formation, particularly in the ovaries and the breast.
"Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage" by Kiyotsugu Yoshida and Yoshio Miki (2004) [1] (http://www.jca.gr.jp/cs/95/11/866.pdf).
Online Mendelian Inheritance in Man: OMIM 600185 (http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600185)
BRCA2 cancer-predisposing mutation is dependent on the method used for DNA analysis and the a priori risk of the person tested of having a mutation in either gene based on the person's cancer history, family history, and ethnic background.
BRCA2 cancer-predisposing mutations with ovariancancer found no difference in survival between individuals with cancer-predisposing mutations and women with ovariancancer in whom genetic testing was negative or unavailable.
BRCA2 mutation were investigated for the presence of cancer of the ovary, male breast, pancreas, prostate, colon, and stomach, and melanoma in first- and second-degree relatives of mutation-positive individuals.
BRCA2 refers to either a gene (BReast-CAncer susceptibility gene 2, located on human chromosome 13, 13q12-13) or the protein coded for by that gene.
Mutations in the genes that code for the BRCA1 and BRCA2 proteins can result in defective repair of damaged DNA, accumulation of mutations, and tumor formation, particularly in the ovaries and the breast.
"Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage" by Kiyotsugu Yoshida and Yoshio Miki (2004) [1].
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