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Encyclopedia > Back mutation

Back mutation is a change in a nucleotide pair, in a mutated gene, that restores the original sequence and hence the original phenotype. The phenotype of an individual organism is either its total physical appearance and constitution or a specific manifestation of a trait, such as size, eye color, or behavior that varies between individuals. ...


References

  • Ellis NA, Ciocci S, German J (2001). "Back mutation can produce phenotype reversion in Bloom syndrome somatic cells". Hum Genet 108 (2): 167-73. PMID 11281456

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mutation: Definition, Synonyms and Much More from Answers.com (7054 words)
Mutations may be induced by exposure to ultraviolet rays and alpha, beta, gamma, and X radiation, by extreme changes in temperature, and by certain mutagenic chemicals such as nitrous acid, nitrogen mustard, and chemical substitutes for portions of the nucleotide subunits of genes.
Mutations can be caused by copying errors in the genetic material during cell division and by exposure to radiation, chemicals (mutagens), or viruses, or can occur deliberately under cellular control during processes such as meiosis or hypermutation.
Mutations create variation in the gene pool, and the less favorable (or deleterious) mutations are removed from the gene pool by natural selection, while more favorable (beneficial or advantageous) ones tend to accumulate — this is evolution.
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