Thomas Harris' Dr. Hannibal Lecter operated a Psychiatric practice in Baltimore before his confinement.
Baltimore is featured in the police procedural books and series based on the work of author and former police reporter David Simon, Homicide: Life on the Street and The Wire.
In addition, Simon's reality-based book and TV miniseries on drug dealers, The Corner, is set in Baltimore.
A significant portion of the Terry Gilliam science fiction thriller Twelve Monkeys takes place in Baltimore.
Several episodes of The X-Files were set in Baltimore.
Baltimore native Tom Clancy, a graduate of Loyola Blakefield and Loyola College in Maryland, often includes Baltimore and other parts of Maryland in his action/spy thriller novels and their corresponding feature films. In the film The Sum of All Fears, based on the Clancy novel of the same name, Baltimore is devastated by a terrorist nuclear bomb. In the book, however, the attack takes place in Denver.
Maryland native Nora Roberts also uses Maryland and particularly parts of the Chesapeake Bay as settings for her novels. This includes Baltimore in such novels as Inner Harbor.
Anne Tyler lived in Baltimore for many years, and many of her books are set there, including The Accidental Tourist, which was also made into a movie.
John Waters' films are all set in Baltimore, and they have all premiered at the historic Senator Theatre.
Laura Lippman is the author of detective fiction set in Baltimore, most notably the Tess Monaghan novels.
The show One on One is set in Baltimore until Breanna moves to Los Angeles for college in season 5 (2005-2006).
The fictional character, Jane Porter, Tarzan's love interest, is a native of Baltimore and the last part of the first Tarzan novel, Tarzan of the Apes, is set there.
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