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Encyclopedia > Barbexaclone

Image:Barbexaclone.png
Barbexaclone

(-)-N,α-Dimethylcyclohexaneethylamine compound with 5-ethyl-5-phenyl-5-phenylbarbituric acid
CAS number
4388-82-3
ATC code
N03AA04
Chemical formula C12H12N2O3.C10H21N
Molecular weight 387.52
Bioavailability  ?
Metabolism  ?
Elimination half-life  ?
Excretion  ?
Pregnancy category  ?
Legal status  ?
Routes of administration  ?

Barbexaclone (marketed in Italy as Maliasin by Abbott Laboratories). It is a salt compound of phenobarbital and propylhexedrine. It was introduced in 1983. It is reported to be as effective as phenobarbital but better tolerated. 100mg of barbexaclone is equivalent to 60mg of phenobarbital. It is not available on prescription in the UK or US. CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother. ... The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... Abbott Laboratories NYSE: ABT is a pharmaceuticals and health care company. ... Phenobarbital (also phenobarbitone or Luminal) is a weak acid with the chemical formula C12H12N2O3. ... Basics: Propylhexedrine is an over-the-counter nasal decongestant found in Benzedrex nasal inhalers. ...


References

  • The Treatment of Epilepsy 2nd Ed by S. D. Shorvon (Editor), David R. Fish (Editor), Emilio Perucca (Editor), W. Edwin Dodson (Editor). Published by Blackwell 2004. ISBN: 0632060468

  Results from FactBites:
 
Essentialdrugs.org (914 words)
The latter drug, used for the last 3 years was found to be particularly useful in the treatment of patients suffering from a post-traumatic psycho-organic syndrome in addition to the PTE.
A therapeutic trial using barbexaclone in uncontrolled seizures was undertaken showing favourable results.
of barbexaclone with acetazolamide with good results in many cases is made.
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