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Encyclopedia > Basiliximab
Image:Basiliximab.png
Basiliximab
Systematic (IUPAC) name
Chimeric murine/human anti-CD25 antibody
Identifiers
CAS number 152923-56-3
ATC code L04AA09
PubChem  ?
DrugBank BTD00073
Chemical data
Formula C6378H9844N1698O1997S48
Mol. weight 143801.3 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

? IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules . ... DrugBank is a database available at the University of Alberta that provides information about thousands of products. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... It has been suggested that this article or section be merged with cell metabolism and carbohydrates. ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...

Legal status
Routes  ?

Basiliximab (Simulect) is a chimeric mouse-human monoclonal antibody to the IL-2Rα receptor of T cells.[1] It is used to prevent rejection in organ transplantation, especially in kidney transplants. It is a Novartis Pharmaceuticals product[2] and was approved by the Food and Drug Administration (FDA) in 1998.[3] The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... Schematic of antibody binding to an antigen An antibody or immunoglobulin is a large Y-shaped protein used by the immune system to identify and neutralize foreign objects like bacteria and viruses. ... Interleukin-2 (IL-2) is an interleukin, a type of biological response modifier, a substance that can improve the bodys natural response to disease. ... T cells are a subset of lymphocytes that play a large role in the immune response. ... Transplant rejection occurs when the immune system of the recipient of a transplant attacks the transplanted organ or tissue. ... An organ transplant is the transplantation of a whole or partial organ from one body to another (or from a donor site on the patients own body), for the purpose of replacing the recipients damaged or failing organ with a working one from the donor site. ... Human kidneys viewed from behind with spine removed The kidneys are bean-shaped excretory organs in vertebrates. ... Novartis Suffern plant is the Swiss companys sole pharmaceutical production facility in the U.S. Novartis International AG is a multinational pharmaceutical company based in Basel, Switzerland. ... The Food and Drug Administration (FDA) is an agency of the United States Department of Health and Human Services and is responsible for regulating food (humans and animal), dietary supplements, drugs (human and animal), cosmetics, medical devices (human and animal) and radiation emitting devices (including non-medical devices), biologics, and... 1998 (MCMXCVIII) was a common year starting on Thursday of the Gregorian calendar, and was designated the International Year of the Ocean. ...


It is given in two doses, the first within 2 hours of the start of the transplant operation and the second 4 days after the transplant. These saturate the receptors and prevent T cell activation and thus prevent formation of antibodies against the transplant. Wikipedia does not yet have an article with this exact name. ...


Like the similar drug daclizumab, basiliximab reduces the incidence and severity of acute rejection in kidney transplantation without increasing the incidence of opportunistic infections. In the United Kingdom, the National Institute for Health and Clinical Excellence has recommended its use be considered for all kidney transplant recipients. Daclizumab (Zenapax) is a murine-human chimaerised monoclonal antibody to the IL-2Rα receptor of T cells. ... Opportunistic infections are infections in immunodeficient patients caused by pathogens which are incapable of causing infection in immunocompetent individuals. ... The National Institute for Health and Clinical Excellence or NICE is an agency of the National Health Service in the United Kingdom. ...


References & Notes

  1. ↑  IL-2Rα receptor is also known as the CD25 T-cell antigen
  2. ↑  Novartis product page for Simulect (basiliximab for injection) . Retrieved 2005-03-09.
  3. ↑  Waldman, Thomas A. (2003). Immunotherapy: past, present and future. Nature Medicine 9, 269-277.


The introduction to this article provides insufficient context for those unfamiliar with the subject matter. ...

Immunosuppressants (L04) edit

Abetimus, Adalimumab, Afelimomab , Anakinra, Alefacept, Antilymphocyte immunoglobulin (horse), Antithymocyte immunoglobulin (rabbit) , Azathioprine, Basiliximab, Ciclosporin, Daclizumab, Efalizumab, Etanercept, Everolimus, Gusperimus , Infliximab, Leflunomide, Methotrexate , Muromonab-CD3 , Mycophenolic acid, Natalizumab, Pimecrolimus, Tacrolimus, Thalidomide, Sirolimus This article needs to be wikified. ... A section of the Anatomical Therapeutic Chemical Classification System. ... Adalimumab (Humira®) is the third TNF antagonist (after infliximab and etanercept) to be approved in the US. Like infliximab and etanercept, adalimumab binds to TNFα, preventing it from activating TNF receptors; adalimumab was constructed from a fully human monoclonal antibody, while infliximab is a mouse-human chimeric antibody and etanercept... // Basic chemical, pharmacological and marketing data Anakinra is an IL-1 receptor antagonist. ... Alefacept is a genetically engineered immunosuppressive drug sold under the brand name Amevive in Canada and the United States. ... Azathioprine is a chemotherapy drug, now rarely used for chemotherapy but more for immunosuppression in organ transplantation, autoimmune disease such as rheumatoid arthritis or inflammatory bowel disease such as Crohns disease. ... Ciclosporin (INN), cyclosporine or cyclosporin (former BAN), is an immunosuppressant drug. ... Daclizumab (Zenapax) is a murine-human chimaerised monoclonal antibody to the IL-2Rα receptor of T cells. ... Efalizumab (Raptiva®, Genentech) is a medication used to treat psoriasis. ... Etanercept (Enbrel®, co-marketed by Amgen and Wyeth) is a human recombinant, soluble tumor necrosis factor-alpha (TNFα) receptor. ... Everolimus is a new mTOR inhibitor drug used as an immunosuppressant to prevent rejection of organ transplants. ... // Chemical Designation Common references are: (+-)-15-Deoxyspergualin, 1-Amino-19-guanidino-11-hydroxy-4,9,12-triazanonadecane-10,13-dione, 15-Deoxyspergualin, 15-Deoxyspergualin Hydrochloride, 7-{(Aminoiminomethyl)amino]-N-[2-[[4-[(3-aminopropyl)amino]butyl]amino]-1-hydroxy-2-oxoethyl]heptanamide, Gusperimus (Trihydrochloride), N-[[[4-[(3-Aminopropyl)amino]-butyl]carbamoyl... It has been suggested that Infliximab (Remicade) be merged into this article or section. ... // Basic Chemical, Pharmacological, and Marketing Data Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD class of drugs, which are chemically and pharmacologically very heterogen. ... Methotrexate (rINN) (IPA: ), abbreviated MTX and formerly known as amethopterin, is an antimetabolite drug used in treatment of cancer and autoimmune diseases. ... Mycophenolic acid (INN) (IPA: ) or mycophenolate is an immunosuppresant drug used to prevent rejection in organ transplantation. ... Natalizumab is a drug co-marketed by Biogen Idec and Élan as Tysabri. ... Pimecrolimus is an immunomodulating agent used in the treatment of atopic dermatitis. ... Tacrolimus (also FK-506 or Fujimycin) is a 23-membered macrolide lactone discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. ... // Thalidomide is a sedative, hypnotic, and anti-inflammatory medication. ... Sirolimus is a relatively new immunosuppressant drug used to prevent rejection in organ transplantation, and is especially useful in kidney transplants. ...


  Results from FactBites:
 
Basiliximab (Systemic) - MayoClinic.com (852 words)
Basiliximab (ba-sil-IK-si-mab) belongs to a group of medicines known as immunosuppressive agents.
Basiliximab is to be administered only by or under the immediate supervision of your doctor.
Preliminary information on the use of basiliximab in children suggests children have the same side effects from receiving basiliximab as those experienced by adult patients, and basiliximab works as well to prevent rejection of the transplanted kidney in children as it does in adult patients.
Basiliximab(Systemic) - [Medication] (795 words)
Basiliximab ba-sil-IK-si-mab belongs to a group of medicines known as immunosuppressive agents.
Basiliximab is to be administered only by or under the immediate supervision of your doctor.
Preliminary information on the use of basiliximab in children suggests children have the same side effects from receiving basiliximab as those experienced by adult patients, and basiliximab works as well to prevent rejection of the transplanted kidney in children as it does in adult patients.
  More results at FactBites »


 

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