The Battle of the Mississinewa also known as the Battle of Mississineway was an expedition ordered by William Henry Harrison against Miami villages in response to the attacks on Fort Wayne.

After receiving permission from Secretary of War William Eustis, Harrison ordered Lt. Col. John B. Campbell to lead an expedition into Indiana. Campbell's objective was to destroy the Miami villages along the Mississinewa River. Campbell's force of 600 mounted troops departed from Fort Greenville on December 14 and travled 80 miles during the middle of winter and reached the Miami village on December 17. Campbell attacked the village and took the Indians by surprise taking 76 prisoners including 34 women and children. Later that day Campbell, having accomplished his objective, considered returning to Fort Greenville on account of severe frostbite among his troopers. The next morning a sizeable Indian force counterattacked Campbell killing 8 Americans and wounding another 48. Despite this, Campbell begins the return march to Fort Greenville taking with him the 76 prisoners. During the return trek the American force suffered greatly from frostbite and by the time they reached Fort Greenville on December 28, some 300 of his troops were suffering from frostbite.

The results of the Battle of the Mississinewa were inconclusive. The Indian force was only concerned with protecting their lives and winter food supplies. In order to ensure this, they simply needed to stop Campbell's expedition and force it to return to it's base. Harrison claimed the expedition as a victory and contemplated sending another expedition down the Mississinewa despite the fact over half his cavalry was incapacitated either from battle wounds or frostbite. Harrison received approval and appointed Campbell a full Colonel in the Regular army.