Benztropine
Systematic (IUPAC) name
3-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane
Identifiers
CAS number	86-13-5
ATC code	N04AC01
PubChem	331152
DrugBank	APRD00748
Chemical data
Formula	C21H25NO
Mol. weight	307.429 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	3-6 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	C Image File history File links Benztropine. ... IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules . ... DrugBank is a database available at the University of Alberta that provides information about thousands of products. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Metabolism (from Greek μεταβολισμός metabolismos) is the biochemical modification of chemical compounds in living organisms and cells. ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...
Legal status
Routes	oral, IM, IV

Benztropine (Cogentin®) is an anticholinergic drug principally used for the treatment of: The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... Intramuscular injection is an injection of a substance directly into a muscle. ... An intravenous drip in a hospital Intravenous therapy or IV therapy is the administration of liquid substances directly into a vein. ... An anticholinergic agent is a member of a class of pharmaceutical compounds which serve to reduce the effects mediated by acetylcholine in the central nervous system and peripheral nervous system. ... Oral medication A medication is a licenced drug taken to cure or reduce symptoms of an illness or medical condition. ...

• Drug-induced parkinsonism, akathisia and acute dystonia;
• Parkinson disease; and
• Idiopathic or secondary dystonia.

Parkinsonism describes the common symptoms of Parkinsons disease - tremor, rigidity, akinesia or bradykinesia and postural instability. ... Akathisia (or acathisia) is an often extremely unpleasant subjective sensation of inner restlessness that manifests itself with an inability to sit still or remain motionless, hence the origin of its name: Greek a (without) + kathesis (sitting). ... Dystonia (literally, abnormal muscle tone) is a generic term used to describe a neurological movement disorder involving involuntary, sustained muscle contractions. ... Idiopathic is a medical adjective that indicates that a recognized cause has not yet been established. ... Secondary can mean: An ordinal adjective indicating Second or second hand, see Primary The secondary in American football refers to the group of (usually four) defensive backs. ... Dystonia (literally, abnormal muscle tone) is a generic term used to describe a neurological movement disorder involving involuntary, sustained muscle contractions. ...

Indications

[[It stimulates 2 PAM--> inhibits toxins]] It is used in patients with schizophrenia to reduce the side effects of antipsychotic treatment, such as parkinsonism and akathisia. The term antipsychotic is applied to a group of drugs used to treat psychosis. ... Parkinsonism describes the common symptoms of Parkinsons disease - tremor, rigidity, akinesia or bradykinesia and postural instability. ... Akathisia (or acathisia) is an often extremely unpleasant subjective sensation of inner restlessness that manifests itself with an inability to sit still or remain motionless, hence the origin of its name: Greek a (without) + kathesis (sitting). ...

Benztropine is also a second-line drug for the treatment of Parkinson's disease. It improves tremor but not rigidity or bradykinesia. For other uses, see Tremor (disambiguation). ...

Benztropine is also sometimes used for the treatment of dystonia, a rare disorder that causes abnormal muscle contraction, resulting in twisting postures of limbs, trunk, or face. Dystonia (literally, abnormal muscle tone) is a generic term used to describe a neurological movement disorder involving involuntary, sustained muscle contractions. ...

Side effects

These are principally anticholinergic:

• Dry mouth
• Blurred vision
• Cognitive changes
• Constipation
• Urinary retention
• Tachycardia
• Anorexia
• Psychosis (usually in overdose)

Some studies suggest that use of anticholinergics increases the risk of tardive dyskinesia, a long-term side effect of antipsychotics.[1][2] Other studies have found no association between anticholinergic exposure and risk of developing tardive dyskinesia.[3] Tardive dyskinesia is a serious neurological disorder caused by the long-term and/or high-dose use of dopamine antagonists, usually antipsychotics and among them especially the typical antipsychotics. ...